Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program

Heterozygous mutations in HNF1B in humans result in a multisystem disorder, including pancreatic hypoplasia and diabetes mellitus. Here we used a well-controlled human induced pluripotent stem cell pancreatic differentiation model to elucidate the molecular mechanisms underlying HNF1B-associated dia...

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Detalles Bibliográficos
Autores principales: El-Khairi, Ranna, Olszanowski, Evelyn, Muraro, Daniele, Madrigal, Pedro, Tilgner, Katarzyna, Chhatriwala, Mariya, Vyas, Sapna, Chia, Crystal Y., Vallier, Ludovic, Rodríguez-Seguí, Santiago A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452540/
https://www.ncbi.nlm.nih.gov/pubmed/34450036
http://dx.doi.org/10.1016/j.stemcr.2021.07.018

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