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High-throughput screening on cochlear organoids identifies VEGFR-MEK-TGFB1 signaling promoting hair cell reprogramming

Hair cell degeneration is a major cause of sensorineural hearing loss. Hair cells in mammalian cochlea do not spontaneously regenerate, posing a great challenge for restoration of hearing. Here, we establish a robust, high-throughput cochlear organoid platform that facilitates 3D expansion of cochle...

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Detalles Bibliográficos
Autores principales:	Liu, Qing, Zhang, Linqing, Zhu, Min-Sheng, Wan, Guoqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452601/ https://www.ncbi.nlm.nih.gov/pubmed/34525385 http://dx.doi.org/10.1016/j.stemcr.2021.08.010

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