Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma

Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. We performed DNA methylation profiling, RNA-seq, and DNA sequencing on 32 RIG tumors and an in vitro drug screen in two RIG cell lines. We report that based on DNA methylation, RIGs cluster p...

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Detalles Bibliográficos
Autores principales: DeSisto, John, Lucas, John T., Xu, Ke, Donson, Andrew, Lin, Tong, Sanford, Bridget, Wu, Gang, Tran, Quynh T., Hedges, Dale, Hsu, Chih-Yang, Armstrong, Gregory T., Arnold, Michael, Bhatia, Smita, Flannery, Patrick, Lemma, Rakeb, Hardie, Lakotah, Schüller, Ulrich, Venkataraman, Sujatha, Hoffman, Lindsey M., Dorris, Kathleen, Mulcahy Levy, Jean M., Hankinson, Todd C., Handler, Michael, Liu, Arthur K., Foreman, Nicholas, Vibhakar, Rajeev, Jones, Kenneth, Allen, Sariah, Zhang, Jinghui, Baker, Suzanne J., Merchant, Thomas E., Orr, Brent A., Green, Adam L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452624/
https://www.ncbi.nlm.nih.gov/pubmed/34545084
http://dx.doi.org/10.1038/s41467-021-25709-x

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