Multi-level inhibition of coronavirus replication by chemical ER stress

Coronaviruses (CoVs) are important human pathogens for which no specific treatment is available. Here, we provide evidence that pharmacological reprogramming of ER stress pathways can be exploited to suppress CoV replication. The ER stress inducer thapsigargin efficiently inhibits coronavirus (HCoV-...

Descripción completa

Detalles Bibliográficos
Autores principales: Shaban, Mohammed Samer, Müller, Christin, Mayr-Buro, Christin, Weiser, Hendrik, Meier-Soelch, Johanna, Albert, Benadict Vincent, Weber, Axel, Linne, Uwe, Hain, Torsten, Babayev, Ilya, Karl, Nadja, Hofmann, Nina, Becker, Stephan, Herold, Susanne, Schmitz, M. Lienhard, Ziebuhr, John, Kracht, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452654/
https://www.ncbi.nlm.nih.gov/pubmed/34545074
http://dx.doi.org/10.1038/s41467-021-25551-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452654/
https://www.ncbi.nlm.nih.gov/pubmed/34545074
http://dx.doi.org/10.1038/s41467-021-25551-1

Ejemplares similares