Cargando…

Multi-level inhibition of coronavirus replication by chemical ER stress

Coronaviruses (CoVs) are important human pathogens for which no specific treatment is available. Here, we provide evidence that pharmacological reprogramming of ER stress pathways can be exploited to suppress CoV replication. The ER stress inducer thapsigargin efficiently inhibits coronavirus (HCoV-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shaban, Mohammed Samer, Müller, Christin, Mayr-Buro, Christin, Weiser, Hendrik, Meier-Soelch, Johanna, Albert, Benadict Vincent, Weber, Axel, Linne, Uwe, Hain, Torsten, Babayev, Ilya, Karl, Nadja, Hofmann, Nina, Becker, Stephan, Herold, Susanne, Schmitz, M. Lienhard, Ziebuhr, John, Kracht, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452654/ https://www.ncbi.nlm.nih.gov/pubmed/34545074 http://dx.doi.org/10.1038/s41467-021-25551-1

Ejemplares similares

Thapsigargin: key to new host-directed coronavirus antivirals?
por: Shaban, Mohammed Samer, et al.
Publicado: (2022)

Reply to: The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein
por: Shaban, Mohammed Samer, et al.
Publicado: (2022)

Monitoring the Levels of Cellular NF-κB Activation States
por: Meier-Soelch, Johanna, et al.
Publicado: (2021)

Single-Cell Analysis of Multiple Steps of Dynamic NF-κB Regulation in Interleukin-1α-Triggered Tumor Cells Using Proximity Ligation Assays
por: Mayr-Buro, Christin, et al.
Publicado: (2019)

The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection
por: Schmitz, M. Lienhard, et al.
Publicado: (2018)

Regulation of Transcription Factor NF-κB in Its Natural Habitat: The Nucleus
por: Bacher, Susanne, et al.
Publicado: (2021)

Distinct IL‐1α‐responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner
por: Weiterer, Sinah‐Sophia, et al.
Publicado: (2019)

Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex
por: Liu, Lu, et al.
Publicado: (2023)

RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes
por: Meier-Soelch, Johanna, et al.
Publicado: (2018)

NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression
por: Riedlinger, Tabea, et al.
Publicado: (2019)

The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells
por: Poppe, Michael, et al.
Publicado: (2017)

The intricate interplay between RNA viruses and NF-κB
por: Schmitz, M. Lienhard, et al.
Publicado: (2014)

Conserved Characteristics of NMPylation Activities of Alpha- and Betacoronavirus NiRAN Domains
por: Slanina, Heiko, et al.
Publicado: (2023)

Post-Transcriptional Control of mRNA Metabolism and Protein Secretion: The Third Level of Regulation within the NF-κB System
por: Priester, Jasmin, et al.
Publicado: (2022)

TRAF6 Phosphorylation Prevents Its Autophagic Degradation and Re-Shapes LPS-Triggered Signaling Networks
por: Busch, Julia, et al.
Publicado: (2021)

Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit
por: Slanina, Heiko, et al.
Publicado: (2021)

Chromatin Targeting of HIPK2 Leads to Acetylation-Dependent Chromatin Decondensation
por: Haas, Jana, et al.
Publicado: (2020)

Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity
por: Obermann, Wiebke, et al.
Publicado: (2022)

The Syk Kinase SmTK4 of Schistosoma mansoni Is Involved in the Regulation of Spermatogenesis and Oogenesis
por: Beckmann, Svenja, et al.
Publicado: (2010)

SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression
por: Schmitz, M. Lienhard, et al.
Publicado: (2022)

The Impact of the Interferon/TNF-Related Apoptosis-Inducing Ligand Signaling Axis on Disease Progression in Respiratory Viral Infection and Beyond
por: Peteranderl, Christin, et al.
Publicado: (2017)

ULK1/2 Restricts the Formation of Inducible SINT-Speckles, Membraneless Organelles Controlling the Threshold of TBK1 Activation
por: Saul, Vera Vivian, et al.
Publicado: (2019)

MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival
por: Bacher, Susanne, et al.
Publicado: (2021)

The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice
por: Riedlinger, Tabea, et al.
Publicado: (2018)

Correction: Riedlinger, T. et al. The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-In Mice. Biomedicines, 2018, 6, 36
por: Riedlinger, Tabea, et al.
Publicado: (2018)

SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism
por: Chillappagari, Shashipavan, et al.
Publicado: (2020)

The rocaglate CR-31-B (−) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo
por: Müller, Christin, et al.
Publicado: (2021)

Hsc70 Is a Novel Interactor of NF-kappaB p65 in Living Hippocampal Neurons
por: Klenke, Christin, et al.
Publicado: (2013)

Dynamic mRNP Remodeling in Response to Internal and External Stimuli
por: Zarnack, Kathi, et al.
Publicado: (2020)

Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5′-termini of RNA and polymerase function
por: Liu, Lu, et al.
Publicado: (2023)

A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress
por: Belapurkar, Ratnal, et al.
Publicado: (2023)

Targeting the DEAD-Box RNA Helicase eIF4A with Rocaglates—A Pan-Antiviral Strategy for Minimizing the Impact of Future RNA Virus Pandemics
por: Taroncher-Oldenburg, Gaspar, et al.
Publicado: (2021)

Ronald D. Laings „radical trip“. Zum Verhältnis von Psychiatrie, Anti-Psychiatrie und Wissenschaft in den 1960er Jahren
por: Lienhard, Marina
Publicado: (2022)

Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression
por: Riedlinger, Tabea, et al.
Publicado: (2019)

Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs
por: Pfafenrot, Christina, et al.
Publicado: (2021)

[5] Characterization of coronavirus RNA polymerase gene products
por: Herold, Jens, et al.
Publicado: (1996)

The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB
por: Ziesché, Elisabeth, et al.
Publicado: (2013)

Localization, Dynamics, and Protein Interactions Reveal Distinct Roles for ER and Golgi SNAREs
por: Hay, Jesse C., et al.
Publicado: (1998)

Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination
por: Li, Haiying, et al.
Publicado: (2011)

HIPK family kinases bind and regulate the function of the CCR4-NOT complex
por: Rodriguez-Gil, Alfonso, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ijbjced4vvnmus1snkds6fjfl2