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Comparison between the areas of scarred and active toxoplasmic retinochoroiditis
BACKGROUND/OBJECTIVES: To assess the ratio of scarred/active areas of fundus lesions in patients with presumed ocular toxoplasmosis. SUBJECTS/METHODS: Retrospective monocentric study of patients with presumed ocular toxoplasmosis seen between May 2004 and February 2018. Patients with a positive anti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452670/ https://www.ncbi.nlm.nih.gov/pubmed/33235345 http://dx.doi.org/10.1038/s41433-020-01290-3 |
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author | Duraffour, Pierre Mehanna, Chadi Hoogewoud, Florence Touboul, Arnaud Monnet, Dominique Brézin, Antoine P. |
author_facet | Duraffour, Pierre Mehanna, Chadi Hoogewoud, Florence Touboul, Arnaud Monnet, Dominique Brézin, Antoine P. |
author_sort | Duraffour, Pierre |
collection | PubMed |
description | BACKGROUND/OBJECTIVES: To assess the ratio of scarred/active areas of fundus lesions in patients with presumed ocular toxoplasmosis. SUBJECTS/METHODS: Retrospective monocentric study of patients with presumed ocular toxoplasmosis seen between May 2004 and February 2018. Patients with a positive anti-Toxoplasma serology presenting characteristic fundus lesions. Cases with images of both baseline active and scarred lesions of the fundus were included. The borders of each active or scarred lesion were delineated on colour photographs by two independent observers and the area of the lesions was calculated using Digimizer 4.2.2 (MedCalc Software, Ostend, Belgium). The interobserver variability of the measures was recorded and their means were used for further calculations. To study the ratio of the area of scarred retinochoroiditis over the area of the baseline active lesion (R). RESULTS: A total of 171 cases (83 males, 88 females) with a mean age of 31.6 ± 13.8 years were included. The average areas of active and scarred retinochoroiditis were, respectively, 1.32 ± 1.59 and 1.79 ± 2.36 optic disc area. The average ratio between scarred and active areas of retinochoroiditis was 1.36 [range 0.54–2.18]. The administration of a systemic treatment [R = 1.25, p = 0.003], the absence of a pre-existing scar [R = 1.05, p < 0.001] and a peripapillary location of the lesion [R = 0.85, p < 0.001] were each significantly associated with smaller scarred/active area ratios. CONCLUSIONS: We assessed in a standardized manner the ratio of scarred/active areas of toxoplasmic lesions and showed that the area of scarred lesions was on average slightly larger than the area of active retinochoroiditis. |
format | Online Article Text |
id | pubmed-8452670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84526702021-10-05 Comparison between the areas of scarred and active toxoplasmic retinochoroiditis Duraffour, Pierre Mehanna, Chadi Hoogewoud, Florence Touboul, Arnaud Monnet, Dominique Brézin, Antoine P. Eye (Lond) Article BACKGROUND/OBJECTIVES: To assess the ratio of scarred/active areas of fundus lesions in patients with presumed ocular toxoplasmosis. SUBJECTS/METHODS: Retrospective monocentric study of patients with presumed ocular toxoplasmosis seen between May 2004 and February 2018. Patients with a positive anti-Toxoplasma serology presenting characteristic fundus lesions. Cases with images of both baseline active and scarred lesions of the fundus were included. The borders of each active or scarred lesion were delineated on colour photographs by two independent observers and the area of the lesions was calculated using Digimizer 4.2.2 (MedCalc Software, Ostend, Belgium). The interobserver variability of the measures was recorded and their means were used for further calculations. To study the ratio of the area of scarred retinochoroiditis over the area of the baseline active lesion (R). RESULTS: A total of 171 cases (83 males, 88 females) with a mean age of 31.6 ± 13.8 years were included. The average areas of active and scarred retinochoroiditis were, respectively, 1.32 ± 1.59 and 1.79 ± 2.36 optic disc area. The average ratio between scarred and active areas of retinochoroiditis was 1.36 [range 0.54–2.18]. The administration of a systemic treatment [R = 1.25, p = 0.003], the absence of a pre-existing scar [R = 1.05, p < 0.001] and a peripapillary location of the lesion [R = 0.85, p < 0.001] were each significantly associated with smaller scarred/active area ratios. CONCLUSIONS: We assessed in a standardized manner the ratio of scarred/active areas of toxoplasmic lesions and showed that the area of scarred lesions was on average slightly larger than the area of active retinochoroiditis. Nature Publishing Group UK 2020-11-24 2021-10 /pmc/articles/PMC8452670/ /pubmed/33235345 http://dx.doi.org/10.1038/s41433-020-01290-3 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Duraffour, Pierre Mehanna, Chadi Hoogewoud, Florence Touboul, Arnaud Monnet, Dominique Brézin, Antoine P. Comparison between the areas of scarred and active toxoplasmic retinochoroiditis |
title | Comparison between the areas of scarred and active toxoplasmic retinochoroiditis |
title_full | Comparison between the areas of scarred and active toxoplasmic retinochoroiditis |
title_fullStr | Comparison between the areas of scarred and active toxoplasmic retinochoroiditis |
title_full_unstemmed | Comparison between the areas of scarred and active toxoplasmic retinochoroiditis |
title_short | Comparison between the areas of scarred and active toxoplasmic retinochoroiditis |
title_sort | comparison between the areas of scarred and active toxoplasmic retinochoroiditis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452670/ https://www.ncbi.nlm.nih.gov/pubmed/33235345 http://dx.doi.org/10.1038/s41433-020-01290-3 |
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