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Unwinding of a DNA replication fork by a hexameric viral helicase

Hexameric helicases are motor proteins that unwind double-stranded DNA (dsDNA) during DNA replication but how they are optimised for strand separation is unclear. Here we present the cryo-EM structure of the full-length E1 helicase from papillomavirus, revealing all arms of a bound DNA replication f...

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Detalles Bibliográficos
Autores principales:	Javed, Abid, Major, Balazs, Stead, Jonathan A., Sanders, Cyril M., Orlova, Elena V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452682/ https://www.ncbi.nlm.nih.gov/pubmed/34545080 http://dx.doi.org/10.1038/s41467-021-25843-6

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