Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid

Isoniazid (INH) is a first-line anti-tuberculosis drug used for nearly 70 years. However, the mechanism underlying the side effects of INH has remained elusive. Here, we report that INH and its metabolites induce a post-translational modification (PTM) of histones, lysine isonicotinylation (K(inic))...

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Detalles Bibliográficos
Autores principales: Jiang, Yuhan, Li, Yixiao, Liu, Cheng, Zhang, Lei, Lv, Danyu, Weng, Yejing, Cheng, Zhongyi, Chen, Xiangmei, Zhan, Jun, Zhang, Hongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452692/
https://www.ncbi.nlm.nih.gov/pubmed/34545082
http://dx.doi.org/10.1038/s41467-021-25867-y

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