LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue

OBJECTIVE: The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently identified antagonist and an inverse agonist of the growth hormone secretagogue receptor (GHSR). GHSR's other well-known endogenous ligand, acyl-ghrelin, increases food intake, body weight, and GH secretion and...

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Detalles Bibliográficos
Autores principales: Shankar, Kripa, Metzger, Nathan P., Singh, Omprakash, Mani, Bharath K., Osborne-Lawrence, Sherri, Varshney, Salil, Gupta, Deepali, Ogden, Sean B., Takemi, Shota, Richard, Corine P., Nandy, Karabi, Liu, Chen, Zigman, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452786/
https://www.ncbi.nlm.nih.gov/pubmed/34428557
http://dx.doi.org/10.1016/j.molmet.2021.101327

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