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Efficient killing of tumor cells by CAR-T cells requires greater number of engaged CARs than TCRs

Although CAR-T cells are widely used to treat cancer, efficiency of CAR-T cell cytolytic responses has not been carefully examined. We engineered CAR specific for HMW-MAA (high-molecular-weight melanoma-associated antigen) and evaluated potency of CD8+ CAR-T cells to release cytolytic granules and t...

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Detalles Bibliográficos
Autores principales:	Anikeeva, Nadia, Panteleev, Sergey, Mazzanti, Nicholas W., Terai, Mizue, Sato, Takami, Sykulev, Yuri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452787/ https://www.ncbi.nlm.nih.gov/pubmed/34371020 http://dx.doi.org/10.1016/j.jbc.2021.101033

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