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Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis?

Objective: Neuroleptic malignant syndrome (NMS) is a rare but severe side effect of antipsychotic medication. Neutrophil-lymphocyte ratio (NLR) is a simple marker used to measure systemic inflammation. Method: In this case report we explore the relationship of inflammation in the etiology of NMS. In...

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Autores principales: Kalelioglu, Tevfik, Celikel, Guler, Balaban, Ozlem Devrim, Karamustafalioglu, Nesrin, Penberthy, Jennifer Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Psychiatry & Psychology Research Center, Tehran University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452834/
https://www.ncbi.nlm.nih.gov/pubmed/34616472
http://dx.doi.org/10.18502/ijps.v16i3.6264
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author Kalelioglu, Tevfik
Celikel, Guler
Balaban, Ozlem Devrim
Karamustafalioglu, Nesrin
Penberthy, Jennifer Kim
author_facet Kalelioglu, Tevfik
Celikel, Guler
Balaban, Ozlem Devrim
Karamustafalioglu, Nesrin
Penberthy, Jennifer Kim
author_sort Kalelioglu, Tevfik
collection PubMed
description Objective: Neuroleptic malignant syndrome (NMS) is a rare but severe side effect of antipsychotic medication. Neutrophil-lymphocyte ratio (NLR) is a simple marker used to measure systemic inflammation. Method: In this case report we explore the relationship of inflammation in the etiology of NMS. In our case involving NMS, although there was no leukocytosis, the NLR was increased up to systemic infection levels. Conclusion: We hypothesized that systemic inflammation may take a role in developing NMS. If so, NLR could be a new marker of NMS that may be able to provide more sensitive results than leukocyte levels.
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spelling pubmed-84528342021-10-05 Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis? Kalelioglu, Tevfik Celikel, Guler Balaban, Ozlem Devrim Karamustafalioglu, Nesrin Penberthy, Jennifer Kim Iran J Psychiatry Case Report Objective: Neuroleptic malignant syndrome (NMS) is a rare but severe side effect of antipsychotic medication. Neutrophil-lymphocyte ratio (NLR) is a simple marker used to measure systemic inflammation. Method: In this case report we explore the relationship of inflammation in the etiology of NMS. In our case involving NMS, although there was no leukocytosis, the NLR was increased up to systemic infection levels. Conclusion: We hypothesized that systemic inflammation may take a role in developing NMS. If so, NLR could be a new marker of NMS that may be able to provide more sensitive results than leukocyte levels. Psychiatry & Psychology Research Center, Tehran University of Medical Sciences 2021-07 /pmc/articles/PMC8452834/ /pubmed/34616472 http://dx.doi.org/10.18502/ijps.v16i3.6264 Text en Copyright © 2021 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Case Report
Kalelioglu, Tevfik
Celikel, Guler
Balaban, Ozlem Devrim
Karamustafalioglu, Nesrin
Penberthy, Jennifer Kim
Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis?
title Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis?
title_full Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis?
title_fullStr Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis?
title_full_unstemmed Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis?
title_short Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis?
title_sort can neutrophil-lymphocyte ratio be a useful criterion for neuroleptic malignant syndrome in the absence of leukocytosis?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452834/
https://www.ncbi.nlm.nih.gov/pubmed/34616472
http://dx.doi.org/10.18502/ijps.v16i3.6264
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