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Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury

Despite changes in guideline-based management of moderate/severe traumatic brain injury (TBI) over the preceding decades, little impact on mortality and morbidity have been seen. This argues against the “one-treatment fits all” approach to such management strategies. With this, some preliminary adva...

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Autores principales: Zeiler, Frederick A., Iturria-Medina, Yasser, Thelin, Eric P., Gomez, Alwyn, Shankar, Jai J., Ko, Ji Hyun, Figley, Chase R., Wright, Galen E. B., Anderson, Chris M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452858/
https://www.ncbi.nlm.nih.gov/pubmed/34557154
http://dx.doi.org/10.3389/fneur.2021.729184
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author Zeiler, Frederick A.
Iturria-Medina, Yasser
Thelin, Eric P.
Gomez, Alwyn
Shankar, Jai J.
Ko, Ji Hyun
Figley, Chase R.
Wright, Galen E. B.
Anderson, Chris M.
author_facet Zeiler, Frederick A.
Iturria-Medina, Yasser
Thelin, Eric P.
Gomez, Alwyn
Shankar, Jai J.
Ko, Ji Hyun
Figley, Chase R.
Wright, Galen E. B.
Anderson, Chris M.
author_sort Zeiler, Frederick A.
collection PubMed
description Despite changes in guideline-based management of moderate/severe traumatic brain injury (TBI) over the preceding decades, little impact on mortality and morbidity have been seen. This argues against the “one-treatment fits all” approach to such management strategies. With this, some preliminary advances in the area of personalized medicine in TBI care have displayed promising results. However, to continue transitioning toward individually-tailored care, we require integration of complex “-omics” data sets. The past few decades have seen dramatic increases in the volume of complex multi-modal data in moderate and severe TBI care. Such data includes serial high-fidelity multi-modal characterization of the cerebral physiome, serum/cerebrospinal fluid proteomics, admission genetic profiles, and serial advanced neuroimaging modalities. Integrating these complex and serially obtained data sets, with patient baseline demographics, treatment information and clinical outcomes over time, can be a daunting task for the treating clinician. Within this review, we highlight the current status of such multi-modal omics data sets in moderate/severe TBI, current limitations to the utilization of such data, and a potential path forward through employing integrative neuroinformatic approaches, which are applied in other neuropathologies. Such advances are positioned to facilitate the transition to precision prognostication and inform a top-down approach to the development of personalized therapeutics in moderate/severe TBI.
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spelling pubmed-84528582021-09-22 Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury Zeiler, Frederick A. Iturria-Medina, Yasser Thelin, Eric P. Gomez, Alwyn Shankar, Jai J. Ko, Ji Hyun Figley, Chase R. Wright, Galen E. B. Anderson, Chris M. Front Neurol Neurology Despite changes in guideline-based management of moderate/severe traumatic brain injury (TBI) over the preceding decades, little impact on mortality and morbidity have been seen. This argues against the “one-treatment fits all” approach to such management strategies. With this, some preliminary advances in the area of personalized medicine in TBI care have displayed promising results. However, to continue transitioning toward individually-tailored care, we require integration of complex “-omics” data sets. The past few decades have seen dramatic increases in the volume of complex multi-modal data in moderate and severe TBI care. Such data includes serial high-fidelity multi-modal characterization of the cerebral physiome, serum/cerebrospinal fluid proteomics, admission genetic profiles, and serial advanced neuroimaging modalities. Integrating these complex and serially obtained data sets, with patient baseline demographics, treatment information and clinical outcomes over time, can be a daunting task for the treating clinician. Within this review, we highlight the current status of such multi-modal omics data sets in moderate/severe TBI, current limitations to the utilization of such data, and a potential path forward through employing integrative neuroinformatic approaches, which are applied in other neuropathologies. Such advances are positioned to facilitate the transition to precision prognostication and inform a top-down approach to the development of personalized therapeutics in moderate/severe TBI. Frontiers Media S.A. 2021-09-07 /pmc/articles/PMC8452858/ /pubmed/34557154 http://dx.doi.org/10.3389/fneur.2021.729184 Text en Copyright © 2021 Zeiler, Iturria-Medina, Thelin, Gomez, Shankar, Ko, Figley, Wright and Anderson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Zeiler, Frederick A.
Iturria-Medina, Yasser
Thelin, Eric P.
Gomez, Alwyn
Shankar, Jai J.
Ko, Ji Hyun
Figley, Chase R.
Wright, Galen E. B.
Anderson, Chris M.
Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury
title Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury
title_full Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury
title_fullStr Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury
title_full_unstemmed Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury
title_short Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury
title_sort integrative neuroinformatics for precision prognostication and personalized therapeutics in moderate and severe traumatic brain injury
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452858/
https://www.ncbi.nlm.nih.gov/pubmed/34557154
http://dx.doi.org/10.3389/fneur.2021.729184
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