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Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease

The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles of environmental light. Fundamental mechanisms of how the circadian clock regulates organ physiology and metabolism have been elucidated at a rapid speed in the past two decades. Here we review circadian networ...

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Autores principales: Li, Min-Dian, Xin, Haoran, Yuan, Yinglin, Yang, Xinqing, Li, Hongli, Tian, Dingyuan, Zhang, Hua, Zhang, Zhihui, Han, Ting-Li, Chen, Qing, Duan, Guangyou, Ju, Dapeng, Chen, Ka, Deng, Fang, He, Wenyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452875/
https://www.ncbi.nlm.nih.gov/pubmed/34557221
http://dx.doi.org/10.3389/fgene.2021.721231
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author Li, Min-Dian
Xin, Haoran
Yuan, Yinglin
Yang, Xinqing
Li, Hongli
Tian, Dingyuan
Zhang, Hua
Zhang, Zhihui
Han, Ting-Li
Chen, Qing
Duan, Guangyou
Ju, Dapeng
Chen, Ka
Deng, Fang
He, Wenyan
author_facet Li, Min-Dian
Xin, Haoran
Yuan, Yinglin
Yang, Xinqing
Li, Hongli
Tian, Dingyuan
Zhang, Hua
Zhang, Zhihui
Han, Ting-Li
Chen, Qing
Duan, Guangyou
Ju, Dapeng
Chen, Ka
Deng, Fang
He, Wenyan
author_sort Li, Min-Dian
collection PubMed
description The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles of environmental light. Fundamental mechanisms of how the circadian clock regulates organ physiology and metabolism have been elucidated at a rapid speed in the past two decades. Here we review circadian networks in more than six organ systems associated with complex disease, which cluster around metabolic disorders, and seek to propose critical regulatory molecules controlled by the circadian clock (named clock-controlled checkpoints) in the pathogenesis of complex disease. These include clock-controlled checkpoints such as circadian nuclear receptors in liver and muscle tissues, chemokines and adhesion molecules in the vasculature. Although the progress is encouraging, many gaps in the mechanisms remain unaddressed. Future studies should focus on devising time-dependent strategies for drug delivery and engagement in well-characterized organs such as the liver, and elucidating fundamental circadian biology in so far less characterized organ systems, including the heart, blood, peripheral neurons, and reproductive systems.
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spelling pubmed-84528752021-09-22 Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease Li, Min-Dian Xin, Haoran Yuan, Yinglin Yang, Xinqing Li, Hongli Tian, Dingyuan Zhang, Hua Zhang, Zhihui Han, Ting-Li Chen, Qing Duan, Guangyou Ju, Dapeng Chen, Ka Deng, Fang He, Wenyan Front Genet Genetics The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles of environmental light. Fundamental mechanisms of how the circadian clock regulates organ physiology and metabolism have been elucidated at a rapid speed in the past two decades. Here we review circadian networks in more than six organ systems associated with complex disease, which cluster around metabolic disorders, and seek to propose critical regulatory molecules controlled by the circadian clock (named clock-controlled checkpoints) in the pathogenesis of complex disease. These include clock-controlled checkpoints such as circadian nuclear receptors in liver and muscle tissues, chemokines and adhesion molecules in the vasculature. Although the progress is encouraging, many gaps in the mechanisms remain unaddressed. Future studies should focus on devising time-dependent strategies for drug delivery and engagement in well-characterized organs such as the liver, and elucidating fundamental circadian biology in so far less characterized organ systems, including the heart, blood, peripheral neurons, and reproductive systems. Frontiers Media S.A. 2021-09-07 /pmc/articles/PMC8452875/ /pubmed/34557221 http://dx.doi.org/10.3389/fgene.2021.721231 Text en Copyright © 2021 Li, Xin, Yuan, Yang, Li, Tian, Zhang, Zhang, Han, Chen, Duan, Ju, Chen, Deng, He and Biological Rhythm Academic Consortium in Chongqing (BRACQ). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Li, Min-Dian
Xin, Haoran
Yuan, Yinglin
Yang, Xinqing
Li, Hongli
Tian, Dingyuan
Zhang, Hua
Zhang, Zhihui
Han, Ting-Li
Chen, Qing
Duan, Guangyou
Ju, Dapeng
Chen, Ka
Deng, Fang
He, Wenyan
Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease
title Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease
title_full Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease
title_fullStr Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease
title_full_unstemmed Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease
title_short Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease
title_sort circadian clock-controlled checkpoints in the pathogenesis of complex disease
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452875/
https://www.ncbi.nlm.nih.gov/pubmed/34557221
http://dx.doi.org/10.3389/fgene.2021.721231
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