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Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach
Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required informatio...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452922/ https://www.ncbi.nlm.nih.gov/pubmed/34557112 http://dx.doi.org/10.3389/fphys.2021.733009 |
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author | Guvenir Torun, Su Torun, Hakki M. Hansen, Hendrik H. G. Gandini, Giulia Berselli, Irene Codazzi, Veronica de Korte, Chris L. van der Steen, Antonius F. W. Migliavacca, Francesco Chiastra, Claudio Akyildiz, Ali C. |
author_facet | Guvenir Torun, Su Torun, Hakki M. Hansen, Hendrik H. G. Gandini, Giulia Berselli, Irene Codazzi, Veronica de Korte, Chris L. van der Steen, Antonius F. W. Migliavacca, Francesco Chiastra, Claudio Akyildiz, Ali C. |
author_sort | Guvenir Torun, Su |
collection | PubMed |
description | Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required information of heterogenous material properties of atherosclerotic coronaries remains to be scarce. In this work, we characterized the component-wise mechanical properties of atherosclerotic human coronary arteries. To achieve this, we performed ex vivo inflation tests on post-mortem human coronary arteries and developed an inverse FE modeling (iFEM) pipeline, which combined high-frequency ultrasound deformation measurements, a high-field magnetic resonance-based artery composition characterization, and a machine learning-based Bayesian optimization (BO) with uniqueness assessment. By using the developed pipeline, 10 cross-sections from five atherosclerotic human coronary arteries were analyzed, and the Yeoh material model constants of the fibrous intima and arterial wall components were determined. This work outlines the developed pipeline and provides the knowledge of non-linear, multicomponent mechanical properties of atherosclerotic human coronary arteries. |
format | Online Article Text |
id | pubmed-8452922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84529222021-09-22 Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach Guvenir Torun, Su Torun, Hakki M. Hansen, Hendrik H. G. Gandini, Giulia Berselli, Irene Codazzi, Veronica de Korte, Chris L. van der Steen, Antonius F. W. Migliavacca, Francesco Chiastra, Claudio Akyildiz, Ali C. Front Physiol Physiology Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required information of heterogenous material properties of atherosclerotic coronaries remains to be scarce. In this work, we characterized the component-wise mechanical properties of atherosclerotic human coronary arteries. To achieve this, we performed ex vivo inflation tests on post-mortem human coronary arteries and developed an inverse FE modeling (iFEM) pipeline, which combined high-frequency ultrasound deformation measurements, a high-field magnetic resonance-based artery composition characterization, and a machine learning-based Bayesian optimization (BO) with uniqueness assessment. By using the developed pipeline, 10 cross-sections from five atherosclerotic human coronary arteries were analyzed, and the Yeoh material model constants of the fibrous intima and arterial wall components were determined. This work outlines the developed pipeline and provides the knowledge of non-linear, multicomponent mechanical properties of atherosclerotic human coronary arteries. Frontiers Media S.A. 2021-09-07 /pmc/articles/PMC8452922/ /pubmed/34557112 http://dx.doi.org/10.3389/fphys.2021.733009 Text en Copyright © 2021 Guvenir Torun, Torun, Hansen, Gandini, Berselli, Codazzi, de Korte, van der Steen, Migliavacca, Chiastra and Akyildiz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Guvenir Torun, Su Torun, Hakki M. Hansen, Hendrik H. G. Gandini, Giulia Berselli, Irene Codazzi, Veronica de Korte, Chris L. van der Steen, Antonius F. W. Migliavacca, Francesco Chiastra, Claudio Akyildiz, Ali C. Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach |
title | Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach |
title_full | Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach |
title_fullStr | Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach |
title_full_unstemmed | Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach |
title_short | Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach |
title_sort | multicomponent mechanical characterization of atherosclerotic human coronary arteries: an experimental and computational hybrid approach |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452922/ https://www.ncbi.nlm.nih.gov/pubmed/34557112 http://dx.doi.org/10.3389/fphys.2021.733009 |
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