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Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach

Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required informatio...

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Autores principales: Guvenir Torun, Su, Torun, Hakki M., Hansen, Hendrik H. G., Gandini, Giulia, Berselli, Irene, Codazzi, Veronica, de Korte, Chris L., van der Steen, Antonius F. W., Migliavacca, Francesco, Chiastra, Claudio, Akyildiz, Ali C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452922/
https://www.ncbi.nlm.nih.gov/pubmed/34557112
http://dx.doi.org/10.3389/fphys.2021.733009
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author Guvenir Torun, Su
Torun, Hakki M.
Hansen, Hendrik H. G.
Gandini, Giulia
Berselli, Irene
Codazzi, Veronica
de Korte, Chris L.
van der Steen, Antonius F. W.
Migliavacca, Francesco
Chiastra, Claudio
Akyildiz, Ali C.
author_facet Guvenir Torun, Su
Torun, Hakki M.
Hansen, Hendrik H. G.
Gandini, Giulia
Berselli, Irene
Codazzi, Veronica
de Korte, Chris L.
van der Steen, Antonius F. W.
Migliavacca, Francesco
Chiastra, Claudio
Akyildiz, Ali C.
author_sort Guvenir Torun, Su
collection PubMed
description Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required information of heterogenous material properties of atherosclerotic coronaries remains to be scarce. In this work, we characterized the component-wise mechanical properties of atherosclerotic human coronary arteries. To achieve this, we performed ex vivo inflation tests on post-mortem human coronary arteries and developed an inverse FE modeling (iFEM) pipeline, which combined high-frequency ultrasound deformation measurements, a high-field magnetic resonance-based artery composition characterization, and a machine learning-based Bayesian optimization (BO) with uniqueness assessment. By using the developed pipeline, 10 cross-sections from five atherosclerotic human coronary arteries were analyzed, and the Yeoh material model constants of the fibrous intima and arterial wall components were determined. This work outlines the developed pipeline and provides the knowledge of non-linear, multicomponent mechanical properties of atherosclerotic human coronary arteries.
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spelling pubmed-84529222021-09-22 Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach Guvenir Torun, Su Torun, Hakki M. Hansen, Hendrik H. G. Gandini, Giulia Berselli, Irene Codazzi, Veronica de Korte, Chris L. van der Steen, Antonius F. W. Migliavacca, Francesco Chiastra, Claudio Akyildiz, Ali C. Front Physiol Physiology Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required information of heterogenous material properties of atherosclerotic coronaries remains to be scarce. In this work, we characterized the component-wise mechanical properties of atherosclerotic human coronary arteries. To achieve this, we performed ex vivo inflation tests on post-mortem human coronary arteries and developed an inverse FE modeling (iFEM) pipeline, which combined high-frequency ultrasound deformation measurements, a high-field magnetic resonance-based artery composition characterization, and a machine learning-based Bayesian optimization (BO) with uniqueness assessment. By using the developed pipeline, 10 cross-sections from five atherosclerotic human coronary arteries were analyzed, and the Yeoh material model constants of the fibrous intima and arterial wall components were determined. This work outlines the developed pipeline and provides the knowledge of non-linear, multicomponent mechanical properties of atherosclerotic human coronary arteries. Frontiers Media S.A. 2021-09-07 /pmc/articles/PMC8452922/ /pubmed/34557112 http://dx.doi.org/10.3389/fphys.2021.733009 Text en Copyright © 2021 Guvenir Torun, Torun, Hansen, Gandini, Berselli, Codazzi, de Korte, van der Steen, Migliavacca, Chiastra and Akyildiz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Guvenir Torun, Su
Torun, Hakki M.
Hansen, Hendrik H. G.
Gandini, Giulia
Berselli, Irene
Codazzi, Veronica
de Korte, Chris L.
van der Steen, Antonius F. W.
Migliavacca, Francesco
Chiastra, Claudio
Akyildiz, Ali C.
Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach
title Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach
title_full Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach
title_fullStr Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach
title_full_unstemmed Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach
title_short Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach
title_sort multicomponent mechanical characterization of atherosclerotic human coronary arteries: an experimental and computational hybrid approach
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452922/
https://www.ncbi.nlm.nih.gov/pubmed/34557112
http://dx.doi.org/10.3389/fphys.2021.733009
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