Cargando…

A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors

Childhood cancer survivors are known to be at risk of chronic co-morbidities, although their risk of COVID-19 infection remains uncertain. Understanding the risk of COVID-19 in this population is necessary to counsel survivors and inform potential mitigation strategies. The objective of this study w...

Descripción completa

Detalles Bibliográficos
Autores principales: Agha, Mohammad, Leung, Felicia, Moineddin, Rahim, Bradley, Nicole M., Gibson, Paul J., Hodgson, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452952/
https://www.ncbi.nlm.nih.gov/pubmed/34557503
http://dx.doi.org/10.3389/fmed.2021.718316
_version_ 1784570187416076288
author Agha, Mohammad
Leung, Felicia
Moineddin, Rahim
Bradley, Nicole M.
Gibson, Paul J.
Hodgson, David C.
author_facet Agha, Mohammad
Leung, Felicia
Moineddin, Rahim
Bradley, Nicole M.
Gibson, Paul J.
Hodgson, David C.
author_sort Agha, Mohammad
collection PubMed
description Childhood cancer survivors are known to be at risk of chronic co-morbidities, although their risk of COVID-19 infection remains uncertain. Understanding the risk of COVID-19 in this population is necessary to counsel survivors and inform potential mitigation strategies. The objective of this study was to determine whether the rates of COVID-19 infection differed between childhood cancer survivors and the general population. Administrative health care data from a population-based registry of children and adolescents diagnosed with cancer in Ontario, Canada, were linked with a universal health insurance registry and a repository of laboratory data. Rates of COVID-19 testing, test positivity and infection between March 1, 2020 and March 31, 2021 among childhood cancer survivors (n = 10 242) were compared to matched controls from the general population (n = 49 068). Compared to the general population, childhood cancer survivors were more likely to have COVID-19 testing (35.9% [95% CI, 34.5–37.4%] vs. 32.0% [95% CI, 31.4–32.6%]), but had a lower likelihood of positive COVID-19 result among those tested (4.3% [95% CI, 3.6–4.9%] vs. 5.5% [95% CI, 5.1–5.8%]) and a similar rate of infection among all subjects at risk (1.5% [95% CI, 1.3–1.8%] vs. 1.7% [95% CI, 1.6–1.9%]). These findings can inform counseling of survivors and clinician recommendations for this population.
format Online
Article
Text
id pubmed-8452952
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-84529522021-09-22 A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors Agha, Mohammad Leung, Felicia Moineddin, Rahim Bradley, Nicole M. Gibson, Paul J. Hodgson, David C. Front Med (Lausanne) Medicine Childhood cancer survivors are known to be at risk of chronic co-morbidities, although their risk of COVID-19 infection remains uncertain. Understanding the risk of COVID-19 in this population is necessary to counsel survivors and inform potential mitigation strategies. The objective of this study was to determine whether the rates of COVID-19 infection differed between childhood cancer survivors and the general population. Administrative health care data from a population-based registry of children and adolescents diagnosed with cancer in Ontario, Canada, were linked with a universal health insurance registry and a repository of laboratory data. Rates of COVID-19 testing, test positivity and infection between March 1, 2020 and March 31, 2021 among childhood cancer survivors (n = 10 242) were compared to matched controls from the general population (n = 49 068). Compared to the general population, childhood cancer survivors were more likely to have COVID-19 testing (35.9% [95% CI, 34.5–37.4%] vs. 32.0% [95% CI, 31.4–32.6%]), but had a lower likelihood of positive COVID-19 result among those tested (4.3% [95% CI, 3.6–4.9%] vs. 5.5% [95% CI, 5.1–5.8%]) and a similar rate of infection among all subjects at risk (1.5% [95% CI, 1.3–1.8%] vs. 1.7% [95% CI, 1.6–1.9%]). These findings can inform counseling of survivors and clinician recommendations for this population. Frontiers Media S.A. 2021-09-07 /pmc/articles/PMC8452952/ /pubmed/34557503 http://dx.doi.org/10.3389/fmed.2021.718316 Text en Copyright © 2021 Agha, Leung, Moineddin, Bradley, Gibson and Hodgson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Agha, Mohammad
Leung, Felicia
Moineddin, Rahim
Bradley, Nicole M.
Gibson, Paul J.
Hodgson, David C.
A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors
title A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors
title_full A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors
title_fullStr A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors
title_full_unstemmed A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors
title_short A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors
title_sort population-based study of covid-19 infection among childhood cancer survivors
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452952/
https://www.ncbi.nlm.nih.gov/pubmed/34557503
http://dx.doi.org/10.3389/fmed.2021.718316
work_keys_str_mv AT aghamohammad apopulationbasedstudyofcovid19infectionamongchildhoodcancersurvivors
AT leungfelicia apopulationbasedstudyofcovid19infectionamongchildhoodcancersurvivors
AT moineddinrahim apopulationbasedstudyofcovid19infectionamongchildhoodcancersurvivors
AT bradleynicolem apopulationbasedstudyofcovid19infectionamongchildhoodcancersurvivors
AT gibsonpaulj apopulationbasedstudyofcovid19infectionamongchildhoodcancersurvivors
AT hodgsondavidc apopulationbasedstudyofcovid19infectionamongchildhoodcancersurvivors
AT aghamohammad populationbasedstudyofcovid19infectionamongchildhoodcancersurvivors
AT leungfelicia populationbasedstudyofcovid19infectionamongchildhoodcancersurvivors
AT moineddinrahim populationbasedstudyofcovid19infectionamongchildhoodcancersurvivors
AT bradleynicolem populationbasedstudyofcovid19infectionamongchildhoodcancersurvivors
AT gibsonpaulj populationbasedstudyofcovid19infectionamongchildhoodcancersurvivors
AT hodgsondavidc populationbasedstudyofcovid19infectionamongchildhoodcancersurvivors