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A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors
Childhood cancer survivors are known to be at risk of chronic co-morbidities, although their risk of COVID-19 infection remains uncertain. Understanding the risk of COVID-19 in this population is necessary to counsel survivors and inform potential mitigation strategies. The objective of this study w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452952/ https://www.ncbi.nlm.nih.gov/pubmed/34557503 http://dx.doi.org/10.3389/fmed.2021.718316 |
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author | Agha, Mohammad Leung, Felicia Moineddin, Rahim Bradley, Nicole M. Gibson, Paul J. Hodgson, David C. |
author_facet | Agha, Mohammad Leung, Felicia Moineddin, Rahim Bradley, Nicole M. Gibson, Paul J. Hodgson, David C. |
author_sort | Agha, Mohammad |
collection | PubMed |
description | Childhood cancer survivors are known to be at risk of chronic co-morbidities, although their risk of COVID-19 infection remains uncertain. Understanding the risk of COVID-19 in this population is necessary to counsel survivors and inform potential mitigation strategies. The objective of this study was to determine whether the rates of COVID-19 infection differed between childhood cancer survivors and the general population. Administrative health care data from a population-based registry of children and adolescents diagnosed with cancer in Ontario, Canada, were linked with a universal health insurance registry and a repository of laboratory data. Rates of COVID-19 testing, test positivity and infection between March 1, 2020 and March 31, 2021 among childhood cancer survivors (n = 10 242) were compared to matched controls from the general population (n = 49 068). Compared to the general population, childhood cancer survivors were more likely to have COVID-19 testing (35.9% [95% CI, 34.5–37.4%] vs. 32.0% [95% CI, 31.4–32.6%]), but had a lower likelihood of positive COVID-19 result among those tested (4.3% [95% CI, 3.6–4.9%] vs. 5.5% [95% CI, 5.1–5.8%]) and a similar rate of infection among all subjects at risk (1.5% [95% CI, 1.3–1.8%] vs. 1.7% [95% CI, 1.6–1.9%]). These findings can inform counseling of survivors and clinician recommendations for this population. |
format | Online Article Text |
id | pubmed-8452952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84529522021-09-22 A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors Agha, Mohammad Leung, Felicia Moineddin, Rahim Bradley, Nicole M. Gibson, Paul J. Hodgson, David C. Front Med (Lausanne) Medicine Childhood cancer survivors are known to be at risk of chronic co-morbidities, although their risk of COVID-19 infection remains uncertain. Understanding the risk of COVID-19 in this population is necessary to counsel survivors and inform potential mitigation strategies. The objective of this study was to determine whether the rates of COVID-19 infection differed between childhood cancer survivors and the general population. Administrative health care data from a population-based registry of children and adolescents diagnosed with cancer in Ontario, Canada, were linked with a universal health insurance registry and a repository of laboratory data. Rates of COVID-19 testing, test positivity and infection between March 1, 2020 and March 31, 2021 among childhood cancer survivors (n = 10 242) were compared to matched controls from the general population (n = 49 068). Compared to the general population, childhood cancer survivors were more likely to have COVID-19 testing (35.9% [95% CI, 34.5–37.4%] vs. 32.0% [95% CI, 31.4–32.6%]), but had a lower likelihood of positive COVID-19 result among those tested (4.3% [95% CI, 3.6–4.9%] vs. 5.5% [95% CI, 5.1–5.8%]) and a similar rate of infection among all subjects at risk (1.5% [95% CI, 1.3–1.8%] vs. 1.7% [95% CI, 1.6–1.9%]). These findings can inform counseling of survivors and clinician recommendations for this population. Frontiers Media S.A. 2021-09-07 /pmc/articles/PMC8452952/ /pubmed/34557503 http://dx.doi.org/10.3389/fmed.2021.718316 Text en Copyright © 2021 Agha, Leung, Moineddin, Bradley, Gibson and Hodgson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Agha, Mohammad Leung, Felicia Moineddin, Rahim Bradley, Nicole M. Gibson, Paul J. Hodgson, David C. A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors |
title | A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors |
title_full | A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors |
title_fullStr | A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors |
title_full_unstemmed | A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors |
title_short | A Population-Based Study of COVID-19 Infection Among Childhood Cancer Survivors |
title_sort | population-based study of covid-19 infection among childhood cancer survivors |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452952/ https://www.ncbi.nlm.nih.gov/pubmed/34557503 http://dx.doi.org/10.3389/fmed.2021.718316 |
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