Cargando…

MLIF Modulates Microglia Polarization in Ischemic Stroke by Targeting eEF1A1

Monocyte locomotion inhibitory factor (MLIF) is a heat-stable pentapeptide from Entamoeba histolytica. Our previous study found that MLIF protects against ischemic stroke in rats and mice and exerts a neuroprotection effect in human neuroblastoma SH-SY5Y cells. Microglia/macrophage polarization has...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yulan, Deng, Shanshan, Song, Zhibing, Zhang, Qian, Guo, Yuchen, Yu, Yongsheng, Wang, Yuliang, Li, Tiejun, Megahed, Fayed A. K., Addissouky, Tamer A., Mao, Junqin, Zhang, Yuefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452963/ https://www.ncbi.nlm.nih.gov/pubmed/34557098 http://dx.doi.org/10.3389/fphar.2021.725268

Ejemplares similares

Network pharmacology and molecular docking-based analysis of protective mechanism of MLIF in ischemic stroke
por: Lv, Mengting, et al.
Publicado: (2022)

MLIF Alleviates SH-SY5Y Neuroblastoma Injury Induced by Oxygen-Glucose Deprivation by Targeting Eukaryotic Translation Elongation Factor 1A2
por: Zhu, Qiuzhen, et al.
Publicado: (2016)

On the Need to Tell Apart Fraternal Twins eEF1A1 and eEF1A2, and Their Respective Outfits
por: Mills, Alberto, et al.
Publicado: (2021)

Novel regulation of the eEF2K/eEF2 pathway: prospects of ‘PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation’
por: Shen, Yuqian, et al.
Publicado: (2021)

Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment
por: Wefers, Zoe, et al.
Publicado: (2022)

High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–actin Complex as a New Potential Target for Therapy
por: Bosutti, Alessandra, et al.
Publicado: (2022)

Characterisation of Translation Elongation Factor eEF1B Subunit Expression in Mammalian Cells and Tissues and Co-Localisation with eEF1A2
por: Cao, Yuan, et al.
Publicado: (2014)

SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy
por: Pires Da Silva, Julie, et al.
Publicado: (2020)

Structural Models of Human eEF1A1 and eEF1A2 Reveal Two Distinct Surface Clusters of Sequence Variation and Potential Differences in Phosphorylation
por: Soares, Dinesh C., et al.
Publicado: (2009)

Coordination of changes in expression and phosphorylation of eukaryotic elongation factor 2 (eEF2) and eEF2 kinase in hypertrophied cardiomyocytes
por: Kameshima, Satoshi, et al.
Publicado: (2016)

Rpl24(Bst) mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
por: Knight, John RP, et al.
Publicado: (2021)

Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localised sites of sequence variation
por: Soares, Dinesh C, et al.
Publicado: (2013)

Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia
por: Xiao, Shan, et al.
Publicado: (2020)

Anti-Inflammatory Dipeptide, a Metabolite from Ambioba Secretion, Protects Cerebral Ischemia Injury by Blocking Apoptosis Via p-JNK/Bax Pathway
por: Zhang, Qian, et al.
Publicado: (2021)

The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections
por: Abbas, Wasim, et al.
Publicado: (2015)

Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis
por: Zhdanov, Alexander V., et al.
Publicado: (2022)

GBAS Regulates the Proliferation and Metastasis of Ovarian Cancer Cells by Combining with eEF1A1
por: Ning, Xin, et al.
Publicado: (2022)

eEF1A1 promotes colorectal cancer progression and predicts poor prognosis of patients
por: Fan, A‐hui, et al.
Publicado: (2022)

Electroacupuncture Improves Synaptic Function in SAMP8 Mice Probably via Inhibition of the AMPK/eEF2K/eEF2 Signaling Pathway
por: Dong, Weiguo, et al.
Publicado: (2019)

A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference
por: Beiser, Tehila, et al.
Publicado: (2022)

The role of protein elongation factor eEF1A2 in ovarian cancer
por: Lee, Jonathan M
Publicado: (2003)

eEF1A Is an S-RNase Binding Factor in Self-Incompatible Solanum chacoense
por: Soulard, Jonathan, et al.
Publicado: (2014)

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells
por: Negrutskii, Boris
Publicado: (2020)

eEF1A1 Overexpression Enhances Tumor Progression and Indicates Poor Prognosis in Hepatocellular Carcinoma
por: Chen, Shi-Lu, et al.
Publicado: (2017)

Cpmer: A new conserved eEF1A2-binding partner that regulates Eomes translation and cardiomyocyte differentiation
por: Lyu, Yao, et al.
Publicado: (2022)

eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts
por: Pisani, Cinzia, et al.
Publicado: (2016)

Ribosome profiling analysis of eEF3-depleted Saccharomyces cerevisiae
por: Kasari, Villu, et al.
Publicado: (2019)

A conserved PUF/Ago/eEF1A complex attenuates translation elongation
por: Friend, Kyle, et al.
Publicado: (2012)

Ethanolamine phosphoglycerol attachment to eEF1A is not essential for normal growth of Trypanosoma brucei
por: Greganova, Eva, et al.
Publicado: (2012)

Analysis of eEF1A2 gene expression and copy number in cervical carcinoma
por: Zheng, Weinan, et al.
Publicado: (2023)

Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes
por: Gismondi, Angelo, et al.
Publicado: (2014)

Cyclo (MQCNS) has the potential to treat ischemic stroke
por: Song, Zhibing, et al.
Publicado: (2023)

Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus
por: Tomlinson, V A L, et al.
Publicado: (2007)

Identification of proteins involved in transcription/translation (eEF 1A1) as an inhibitor of Bax induced apoptosis
por: Akintade, Damilare D., et al.
Publicado: (2020)

An eEF1A1 truncation encoded by PTI-1 exerts its oncogenic effect inside the nucleus
por: Dahl, Louise D, et al.
Publicado: (2014)

The eEF1γ Subunit Contacts RNA Polymerase II and Binds Vimentin Promoter Region
por: Corbi, Nicoletta, et al.
Publicado: (2010)

Collaboration of tRNA modifications and elongation factor eEF1A in decoding and nonsense suppression
por: Klassen, Roland, et al.
Publicado: (2018)

Antibody toolkit to investigate eEF1A methylation dynamics in mRNA translation elongation
por: Mealey-Farr, Robert, et al.
Publicado: (2023)

Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Cancer
por: Wang, Xuemin, et al.
Publicado: (2017)

Tanshinone IIA Protects Against Cerebral Ischemia Reperfusion Injury by Regulating Microglial Activation and Polarization via NF-κB Pathway
por: Song, Zhibing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sig1hoqn2ah75dhvgaucssecuu