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MicroRNA-21: An Emerging Player in Bone Diseases

MicroRNAs (MiRNAs) are small endogenous non-coding RNAs that bind to the 3′-untranslated region of target genes and promote their degradation or inhibit translation, thereby regulating gene expression. MiRNAs are ubiquitous in biology and are involved in many biological processes, playing an importa...

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Autores principales: Chen, Chen, Liu, Ya-Mei, Fu, Bin-Lan, Xu, Liang-Liang, Wang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452984/
https://www.ncbi.nlm.nih.gov/pubmed/34557095
http://dx.doi.org/10.3389/fphar.2021.722804
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author Chen, Chen
Liu, Ya-Mei
Fu, Bin-Lan
Xu, Liang-Liang
Wang, Bin
author_facet Chen, Chen
Liu, Ya-Mei
Fu, Bin-Lan
Xu, Liang-Liang
Wang, Bin
author_sort Chen, Chen
collection PubMed
description MicroRNAs (MiRNAs) are small endogenous non-coding RNAs that bind to the 3′-untranslated region of target genes and promote their degradation or inhibit translation, thereby regulating gene expression. MiRNAs are ubiquitous in biology and are involved in many biological processes, playing an important role in a variety of physiological and pathological processes. MiRNA-21 (miR-21) is one of them. In recent years, miR-21 has received a lot of attention from researchers as an emerging player in orthopedic diseases. MiR-21 is closely associated with the occurrence, development, treatment, and prevention of orthopedic diseases through a variety of mechanisms. This review summarizes its effects on osteoblasts, osteoclasts and their relationship with osteoporosis, fracture, osteoarthritis (OA), osteonecrosis, providing a new way of thinking for the diagnosis, treatment and prevention of these bone diseases.
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spelling pubmed-84529842021-09-22 MicroRNA-21: An Emerging Player in Bone Diseases Chen, Chen Liu, Ya-Mei Fu, Bin-Lan Xu, Liang-Liang Wang, Bin Front Pharmacol Pharmacology MicroRNAs (MiRNAs) are small endogenous non-coding RNAs that bind to the 3′-untranslated region of target genes and promote their degradation or inhibit translation, thereby regulating gene expression. MiRNAs are ubiquitous in biology and are involved in many biological processes, playing an important role in a variety of physiological and pathological processes. MiRNA-21 (miR-21) is one of them. In recent years, miR-21 has received a lot of attention from researchers as an emerging player in orthopedic diseases. MiR-21 is closely associated with the occurrence, development, treatment, and prevention of orthopedic diseases through a variety of mechanisms. This review summarizes its effects on osteoblasts, osteoclasts and their relationship with osteoporosis, fracture, osteoarthritis (OA), osteonecrosis, providing a new way of thinking for the diagnosis, treatment and prevention of these bone diseases. Frontiers Media S.A. 2021-09-07 /pmc/articles/PMC8452984/ /pubmed/34557095 http://dx.doi.org/10.3389/fphar.2021.722804 Text en Copyright © 2021 Chen, Liu, Fu, Xu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Chen
Liu, Ya-Mei
Fu, Bin-Lan
Xu, Liang-Liang
Wang, Bin
MicroRNA-21: An Emerging Player in Bone Diseases
title MicroRNA-21: An Emerging Player in Bone Diseases
title_full MicroRNA-21: An Emerging Player in Bone Diseases
title_fullStr MicroRNA-21: An Emerging Player in Bone Diseases
title_full_unstemmed MicroRNA-21: An Emerging Player in Bone Diseases
title_short MicroRNA-21: An Emerging Player in Bone Diseases
title_sort microrna-21: an emerging player in bone diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452984/
https://www.ncbi.nlm.nih.gov/pubmed/34557095
http://dx.doi.org/10.3389/fphar.2021.722804
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