Structural determinants of peptide-dependent TAP1-TAP2 transit passage targeted by viral proteins and altered by cancer-associated mutations

The TAP1-TAP2 complex transports antigenic peptide substrates into the endoplasmic reticulum (ER). In ER, the peptides are further processed and loaded on the major histocompatibility class (MHC) I molecules by the peptide loading complex (PLC). The TAP transporters are linked with the PLC; a target...

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Detalles Bibliográficos
Autores principales: Padariya, Monikaben, Kote, Sachin, Mayordomo, Marcos, Dapic, Irena, Alfaro, Javier, Hupp, Ted, Fahraeus, Robin, Kalathiya, Umesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453138/
https://www.ncbi.nlm.nih.gov/pubmed/34589184
http://dx.doi.org/10.1016/j.csbj.2021.09.006

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