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Differential Effects of Estrogen Receptor Alpha and Beta on Endogenous Ligands of Peroxisome Proliferator-Activated Receptor Gamma in Papillary Thyroid Cancer
PURPOSE: The inhibition of estrogen receptor alpha (ERα) or the activation of ERβ can inhibit papillary thyroid cancer (PTC), but the precise mechanism is not known. We aimed to explore the role of ERα and ERβ on the production of endogenous peroxisome proliferator-activated receptor gamma (PPARγ) l...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453163/ https://www.ncbi.nlm.nih.gov/pubmed/34557159 http://dx.doi.org/10.3389/fendo.2021.708248 |
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author | Yang, Shucai Gong, Zhongqin Liu, Zhimin Wei, Minghui Xue, Lingbin Vlantis, Alexander C. Zhang, Yang Chan, Jason YK. van Hasselt, C Andrew Zeng, Xianhai Qiu, Shuqi Tang, Nelson Du, Jing Wei, Wei Tong, Michael CF Chen, George G. |
author_facet | Yang, Shucai Gong, Zhongqin Liu, Zhimin Wei, Minghui Xue, Lingbin Vlantis, Alexander C. Zhang, Yang Chan, Jason YK. van Hasselt, C Andrew Zeng, Xianhai Qiu, Shuqi Tang, Nelson Du, Jing Wei, Wei Tong, Michael CF Chen, George G. |
author_sort | Yang, Shucai |
collection | PubMed |
description | PURPOSE: The inhibition of estrogen receptor alpha (ERα) or the activation of ERβ can inhibit papillary thyroid cancer (PTC), but the precise mechanism is not known. We aimed to explore the role of ERα and ERβ on the production of endogenous peroxisome proliferator-activated receptor gamma (PPARγ) ligands in PTC. METHODS: 2 PTC cell lines, 32 pairs of PTC tissues and matched normal thyroid tissues were used in this study. The levels of endogenous PPARγ ligands 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), 13-S-hydroxyoctadecadienoic acid (13(S)-HODE), and15-deoxy-Δ12,14-prostaglandin J2 (PGJ2) were measured by ELISA. RESULTS: The levels of PGJ2 and 15(S)-HETE were significantly reduced in PTC, but 13(S)-HODE was not changed. Activation of ERα or inhibition of ERβ significantly downregulated the production of PGJ2, 15(S)-HETE and 13(S)-HODE, whereas inhibition of ERα or activation of ERβ markedly upregulated the production of these three ligands. Application of endogenous PPARγ ligands inhibited growth, induced apoptosis of cancer cells, and promoted the efficacy of chemotherapy. CONCLUSION: The levels of endogenous PPARγ ligands PGJ2 and 15(S)-HETE are significantly decreased in PTC. The inhibition of ERα or activation of ERβ can inhibit PTC by stimulating the production of endogenous PPARγ ligands to induce apoptosis in cancer cells. |
format | Online Article Text |
id | pubmed-8453163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84531632021-09-22 Differential Effects of Estrogen Receptor Alpha and Beta on Endogenous Ligands of Peroxisome Proliferator-Activated Receptor Gamma in Papillary Thyroid Cancer Yang, Shucai Gong, Zhongqin Liu, Zhimin Wei, Minghui Xue, Lingbin Vlantis, Alexander C. Zhang, Yang Chan, Jason YK. van Hasselt, C Andrew Zeng, Xianhai Qiu, Shuqi Tang, Nelson Du, Jing Wei, Wei Tong, Michael CF Chen, George G. Front Endocrinol (Lausanne) Endocrinology PURPOSE: The inhibition of estrogen receptor alpha (ERα) or the activation of ERβ can inhibit papillary thyroid cancer (PTC), but the precise mechanism is not known. We aimed to explore the role of ERα and ERβ on the production of endogenous peroxisome proliferator-activated receptor gamma (PPARγ) ligands in PTC. METHODS: 2 PTC cell lines, 32 pairs of PTC tissues and matched normal thyroid tissues were used in this study. The levels of endogenous PPARγ ligands 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), 13-S-hydroxyoctadecadienoic acid (13(S)-HODE), and15-deoxy-Δ12,14-prostaglandin J2 (PGJ2) were measured by ELISA. RESULTS: The levels of PGJ2 and 15(S)-HETE were significantly reduced in PTC, but 13(S)-HODE was not changed. Activation of ERα or inhibition of ERβ significantly downregulated the production of PGJ2, 15(S)-HETE and 13(S)-HODE, whereas inhibition of ERα or activation of ERβ markedly upregulated the production of these three ligands. Application of endogenous PPARγ ligands inhibited growth, induced apoptosis of cancer cells, and promoted the efficacy of chemotherapy. CONCLUSION: The levels of endogenous PPARγ ligands PGJ2 and 15(S)-HETE are significantly decreased in PTC. The inhibition of ERα or activation of ERβ can inhibit PTC by stimulating the production of endogenous PPARγ ligands to induce apoptosis in cancer cells. Frontiers Media S.A. 2021-09-07 /pmc/articles/PMC8453163/ /pubmed/34557159 http://dx.doi.org/10.3389/fendo.2021.708248 Text en Copyright © 2021 Yang, Gong, Liu, Wei, Xue, Vlantis, Zhang, Chan, van Hasselt, Zeng, Qiu, Tang, Du, Wei, Tong and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Yang, Shucai Gong, Zhongqin Liu, Zhimin Wei, Minghui Xue, Lingbin Vlantis, Alexander C. Zhang, Yang Chan, Jason YK. van Hasselt, C Andrew Zeng, Xianhai Qiu, Shuqi Tang, Nelson Du, Jing Wei, Wei Tong, Michael CF Chen, George G. Differential Effects of Estrogen Receptor Alpha and Beta on Endogenous Ligands of Peroxisome Proliferator-Activated Receptor Gamma in Papillary Thyroid Cancer |
title | Differential Effects of Estrogen Receptor Alpha and Beta on Endogenous Ligands of Peroxisome Proliferator-Activated Receptor Gamma in Papillary Thyroid Cancer |
title_full | Differential Effects of Estrogen Receptor Alpha and Beta on Endogenous Ligands of Peroxisome Proliferator-Activated Receptor Gamma in Papillary Thyroid Cancer |
title_fullStr | Differential Effects of Estrogen Receptor Alpha and Beta on Endogenous Ligands of Peroxisome Proliferator-Activated Receptor Gamma in Papillary Thyroid Cancer |
title_full_unstemmed | Differential Effects of Estrogen Receptor Alpha and Beta on Endogenous Ligands of Peroxisome Proliferator-Activated Receptor Gamma in Papillary Thyroid Cancer |
title_short | Differential Effects of Estrogen Receptor Alpha and Beta on Endogenous Ligands of Peroxisome Proliferator-Activated Receptor Gamma in Papillary Thyroid Cancer |
title_sort | differential effects of estrogen receptor alpha and beta on endogenous ligands of peroxisome proliferator-activated receptor gamma in papillary thyroid cancer |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453163/ https://www.ncbi.nlm.nih.gov/pubmed/34557159 http://dx.doi.org/10.3389/fendo.2021.708248 |
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