Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study

Aim: The objective was to investigate the effect of metamizole on renal function in healthy, salt-depleted volunteers. In addition, the pharmacokinetics of the four major metamizole metabolites were assessed and correlated with the pharmacodynamic effect using urinary excretion of the prostacyclin m...

Descripción completa

Detalles Bibliográficos
Autores principales: Blaser, Lea S, Duthaler, Urs, Bouitbir, Jamal, Leuppi-Taegtmeyer, Anne B, Liakoni, Evangelia, Dolf, Reto, Mayr, Michael, Drewe, Jürgen, Krähenbühl, Stephan, Haschke, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453264/
https://www.ncbi.nlm.nih.gov/pubmed/34557087
http://dx.doi.org/10.3389/fphar.2021.620635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453264/
https://www.ncbi.nlm.nih.gov/pubmed/34557087
http://dx.doi.org/10.3389/fphar.2021.620635

Ejemplares similares