Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans

The interneurons ALA and RIS both regulate stress induced sleep in C. elegans but their roles in awake animal movement has been reported to differ. We describe the development of a motivated mobility-based assay that distinguishes between animals mutant for ALA function and those mutant for RIS func...

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Autores principales: Chávez-Pérez, Carlos, Jafari, Niusha, Keenan, Brendan T, Raizen, David M, Rohacek, Alex M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453304/
https://www.ncbi.nlm.nih.gov/pubmed/34557657
http://dx.doi.org/10.17912/micropub.biology.000468
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author Chávez-Pérez, Carlos
Jafari, Niusha
Keenan, Brendan T
Raizen, David M
Rohacek, Alex M
author_facet Chávez-Pérez, Carlos
Jafari, Niusha
Keenan, Brendan T
Raizen, David M
Rohacek, Alex M
author_sort Chávez-Pérez, Carlos
collection PubMed
description The interneurons ALA and RIS both regulate stress induced sleep in C. elegans but their roles in awake animal movement has been reported to differ. We describe the development of a motivated mobility-based assay that distinguishes between animals mutant for ALA function and those mutant for RIS function.
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spelling pubmed-84533042021-09-22 Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans Chávez-Pérez, Carlos Jafari, Niusha Keenan, Brendan T Raizen, David M Rohacek, Alex M MicroPubl Biol New Finding The interneurons ALA and RIS both regulate stress induced sleep in C. elegans but their roles in awake animal movement has been reported to differ. We describe the development of a motivated mobility-based assay that distinguishes between animals mutant for ALA function and those mutant for RIS function. Caltech Library 2021-09-20 /pmc/articles/PMC8453304/ /pubmed/34557657 http://dx.doi.org/10.17912/micropub.biology.000468 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Chávez-Pérez, Carlos
Jafari, Niusha
Keenan, Brendan T
Raizen, David M
Rohacek, Alex M
Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans
title Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans
title_full Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans
title_fullStr Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans
title_full_unstemmed Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans
title_short Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans
title_sort motivated displacement assay distinguishes ala neuron mutants from ris neuron mutants during recovery from heat stress in caenorhabditis elegans
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453304/
https://www.ncbi.nlm.nih.gov/pubmed/34557657
http://dx.doi.org/10.17912/micropub.biology.000468
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