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Gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats
Gentianella acuta (G. acuta) has been widely used as a traditional medicine by Chinese Mongolian populations for the treatment of heart diseases and has also been tested in modern pharmacological experiments. However, the effects of G. acuta on cardiovascular damage and inflammation under conditions...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453326/ https://www.ncbi.nlm.nih.gov/pubmed/34603527 http://dx.doi.org/10.3892/etm.2021.10694 |
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author | Si, Mingdong Wu, Meng Huo, Yingying Li, Aiying Guan, Shengjiang Ma, Donglai Ma, Zhihong |
author_facet | Si, Mingdong Wu, Meng Huo, Yingying Li, Aiying Guan, Shengjiang Ma, Donglai Ma, Zhihong |
author_sort | Si, Mingdong |
collection | PubMed |
description | Gentianella acuta (G. acuta) has been widely used as a traditional medicine by Chinese Mongolian populations for the treatment of heart diseases and has also been tested in modern pharmacological experiments. However, the effects of G. acuta on cardiovascular damage and inflammation under conditions of hypercholesterolaemia remain unclear. The present study investigated the effects and mechanisms of the water extract of G. acuta on cardiovascular damage and inflammation caused by a high-cholesterol diet. Male Sprague-Dawley rats were fed a high-cholesterol diet for 4 weeks to establish the hypercholesterolaemia rat model, and they were administered physiological saline or 1.2 g/kg of G. acuta by gavage starting from the 15th day. After the last administration, the blood, heart and thoracic aorta samples were collected and examined. It was revealed that G. acuta treatment could ameliorate cardiomyocyte disorder and thoracic aortic vessel wall damage, reduce serum lipid levels and inflammatory factors and improve heart function. Compared with the Model group, the serum levels of triglycerides, total cholesterol, low-density lipoprotein and tumour necrosis factor-α were decreased, and the high-density lipoprotein and interleukin-10 levels were increased in the Model-G group. Moreover, in both the heart and thoracic aorta, G. acuta reduced the expression and phosphorylation of inhibitor of nuclear factor kappa-B kinase β (IKKβ), inhibitor of NF-κB-α (IκBα) and p-nuclear factor kappa-B (NF-κB). Therefore, G. acuta may exert an inhibitory effect on the IKK/IκB/NF-κB signalling pathway to protect the heart and thoracic aorta in hypercholesterolaemic rats. |
format | Online Article Text |
id | pubmed-8453326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-84533262021-09-30 Gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats Si, Mingdong Wu, Meng Huo, Yingying Li, Aiying Guan, Shengjiang Ma, Donglai Ma, Zhihong Exp Ther Med Articles Gentianella acuta (G. acuta) has been widely used as a traditional medicine by Chinese Mongolian populations for the treatment of heart diseases and has also been tested in modern pharmacological experiments. However, the effects of G. acuta on cardiovascular damage and inflammation under conditions of hypercholesterolaemia remain unclear. The present study investigated the effects and mechanisms of the water extract of G. acuta on cardiovascular damage and inflammation caused by a high-cholesterol diet. Male Sprague-Dawley rats were fed a high-cholesterol diet for 4 weeks to establish the hypercholesterolaemia rat model, and they were administered physiological saline or 1.2 g/kg of G. acuta by gavage starting from the 15th day. After the last administration, the blood, heart and thoracic aorta samples were collected and examined. It was revealed that G. acuta treatment could ameliorate cardiomyocyte disorder and thoracic aortic vessel wall damage, reduce serum lipid levels and inflammatory factors and improve heart function. Compared with the Model group, the serum levels of triglycerides, total cholesterol, low-density lipoprotein and tumour necrosis factor-α were decreased, and the high-density lipoprotein and interleukin-10 levels were increased in the Model-G group. Moreover, in both the heart and thoracic aorta, G. acuta reduced the expression and phosphorylation of inhibitor of nuclear factor kappa-B kinase β (IKKβ), inhibitor of NF-κB-α (IκBα) and p-nuclear factor kappa-B (NF-κB). Therefore, G. acuta may exert an inhibitory effect on the IKK/IκB/NF-κB signalling pathway to protect the heart and thoracic aorta in hypercholesterolaemic rats. D.A. Spandidos 2021-11 2021-09-06 /pmc/articles/PMC8453326/ /pubmed/34603527 http://dx.doi.org/10.3892/etm.2021.10694 Text en Copyright: © Si et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Articles Si, Mingdong Wu, Meng Huo, Yingying Li, Aiying Guan, Shengjiang Ma, Donglai Ma, Zhihong Gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats |
title | Gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats |
title_full | Gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats |
title_fullStr | Gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats |
title_full_unstemmed | Gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats |
title_short | Gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats |
title_sort | gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453326/ https://www.ncbi.nlm.nih.gov/pubmed/34603527 http://dx.doi.org/10.3892/etm.2021.10694 |
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