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Expression and prognostic value of TRPM7 in canine mammary tumours

Canine mammary gland tumour (CMTs) are one of the most commonly found tumours in intact female dogs. A previous study on canine mammary glands demonstrated the presence of the transient receptor potential melastatin 7 (TRPM7) ion channels in healthy canine mammary tissues. However, the significance...

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Autores principales: Lee, Seulji, Lee, Sungin, Kim, Wan Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453503/
https://www.ncbi.nlm.nih.gov/pubmed/33617107
http://dx.doi.org/10.1111/vco.12689
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author Lee, Seulji
Lee, Sungin
Kim, Wan Hee
author_facet Lee, Seulji
Lee, Sungin
Kim, Wan Hee
author_sort Lee, Seulji
collection PubMed
description Canine mammary gland tumour (CMTs) are one of the most commonly found tumours in intact female dogs. A previous study on canine mammary glands demonstrated the presence of the transient receptor potential melastatin 7 (TRPM7) ion channels in healthy canine mammary tissues. However, the significance of TRPM7 in CMT is not yet known. TRPM7 is a Ca(2+) and Mg(2+) permeable cation channel that contains a protein kinase domain. The aim of this study was to determine TRPM7 expression in 57 benign and malignant CMT tissues of dogs using immunohistochemistry (IHC) and evaluate its correlation with clinicopathological features and explore the potential prognostic value of TRPM7 in a prospective survival study. IHC analysis shows that TRPM7 was expressed in the cytoplasm of neoplastic epithelial cells. Moreover, TRPM7 expression was significantly associated with tumour malignancy (P = .027), Ki‐67 index (P < .0001) and metastasis (P < .0001). Survival curve analysis indicates that high TRPM7 expression was significantly associated with poor disease‐free (P = .035) and overall survival (P = .011) in malignant CMTs. Our results demonstrate that TRPM7 is expressed in CMTs and that its expression is positively correlated with clinicopathological parameters. Thus, TRPM7 was assumed to be a potential prognostic factor for CMTs.
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spelling pubmed-84535032021-09-27 Expression and prognostic value of TRPM7 in canine mammary tumours Lee, Seulji Lee, Sungin Kim, Wan Hee Vet Comp Oncol Original Articles Canine mammary gland tumour (CMTs) are one of the most commonly found tumours in intact female dogs. A previous study on canine mammary glands demonstrated the presence of the transient receptor potential melastatin 7 (TRPM7) ion channels in healthy canine mammary tissues. However, the significance of TRPM7 in CMT is not yet known. TRPM7 is a Ca(2+) and Mg(2+) permeable cation channel that contains a protein kinase domain. The aim of this study was to determine TRPM7 expression in 57 benign and malignant CMT tissues of dogs using immunohistochemistry (IHC) and evaluate its correlation with clinicopathological features and explore the potential prognostic value of TRPM7 in a prospective survival study. IHC analysis shows that TRPM7 was expressed in the cytoplasm of neoplastic epithelial cells. Moreover, TRPM7 expression was significantly associated with tumour malignancy (P = .027), Ki‐67 index (P < .0001) and metastasis (P < .0001). Survival curve analysis indicates that high TRPM7 expression was significantly associated with poor disease‐free (P = .035) and overall survival (P = .011) in malignant CMTs. Our results demonstrate that TRPM7 is expressed in CMTs and that its expression is positively correlated with clinicopathological parameters. Thus, TRPM7 was assumed to be a potential prognostic factor for CMTs. Blackwell Publishing Ltd 2021-05-04 2021-09 /pmc/articles/PMC8453503/ /pubmed/33617107 http://dx.doi.org/10.1111/vco.12689 Text en © 2021 The Authors. Veterinary and Comparative Oncology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Lee, Seulji
Lee, Sungin
Kim, Wan Hee
Expression and prognostic value of TRPM7 in canine mammary tumours
title Expression and prognostic value of TRPM7 in canine mammary tumours
title_full Expression and prognostic value of TRPM7 in canine mammary tumours
title_fullStr Expression and prognostic value of TRPM7 in canine mammary tumours
title_full_unstemmed Expression and prognostic value of TRPM7 in canine mammary tumours
title_short Expression and prognostic value of TRPM7 in canine mammary tumours
title_sort expression and prognostic value of trpm7 in canine mammary tumours
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453503/
https://www.ncbi.nlm.nih.gov/pubmed/33617107
http://dx.doi.org/10.1111/vco.12689
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