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Expression and prognostic value of TRPM7 in canine mammary tumours
Canine mammary gland tumour (CMTs) are one of the most commonly found tumours in intact female dogs. A previous study on canine mammary glands demonstrated the presence of the transient receptor potential melastatin 7 (TRPM7) ion channels in healthy canine mammary tissues. However, the significance...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453503/ https://www.ncbi.nlm.nih.gov/pubmed/33617107 http://dx.doi.org/10.1111/vco.12689 |
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author | Lee, Seulji Lee, Sungin Kim, Wan Hee |
author_facet | Lee, Seulji Lee, Sungin Kim, Wan Hee |
author_sort | Lee, Seulji |
collection | PubMed |
description | Canine mammary gland tumour (CMTs) are one of the most commonly found tumours in intact female dogs. A previous study on canine mammary glands demonstrated the presence of the transient receptor potential melastatin 7 (TRPM7) ion channels in healthy canine mammary tissues. However, the significance of TRPM7 in CMT is not yet known. TRPM7 is a Ca(2+) and Mg(2+) permeable cation channel that contains a protein kinase domain. The aim of this study was to determine TRPM7 expression in 57 benign and malignant CMT tissues of dogs using immunohistochemistry (IHC) and evaluate its correlation with clinicopathological features and explore the potential prognostic value of TRPM7 in a prospective survival study. IHC analysis shows that TRPM7 was expressed in the cytoplasm of neoplastic epithelial cells. Moreover, TRPM7 expression was significantly associated with tumour malignancy (P = .027), Ki‐67 index (P < .0001) and metastasis (P < .0001). Survival curve analysis indicates that high TRPM7 expression was significantly associated with poor disease‐free (P = .035) and overall survival (P = .011) in malignant CMTs. Our results demonstrate that TRPM7 is expressed in CMTs and that its expression is positively correlated with clinicopathological parameters. Thus, TRPM7 was assumed to be a potential prognostic factor for CMTs. |
format | Online Article Text |
id | pubmed-8453503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-84535032021-09-27 Expression and prognostic value of TRPM7 in canine mammary tumours Lee, Seulji Lee, Sungin Kim, Wan Hee Vet Comp Oncol Original Articles Canine mammary gland tumour (CMTs) are one of the most commonly found tumours in intact female dogs. A previous study on canine mammary glands demonstrated the presence of the transient receptor potential melastatin 7 (TRPM7) ion channels in healthy canine mammary tissues. However, the significance of TRPM7 in CMT is not yet known. TRPM7 is a Ca(2+) and Mg(2+) permeable cation channel that contains a protein kinase domain. The aim of this study was to determine TRPM7 expression in 57 benign and malignant CMT tissues of dogs using immunohistochemistry (IHC) and evaluate its correlation with clinicopathological features and explore the potential prognostic value of TRPM7 in a prospective survival study. IHC analysis shows that TRPM7 was expressed in the cytoplasm of neoplastic epithelial cells. Moreover, TRPM7 expression was significantly associated with tumour malignancy (P = .027), Ki‐67 index (P < .0001) and metastasis (P < .0001). Survival curve analysis indicates that high TRPM7 expression was significantly associated with poor disease‐free (P = .035) and overall survival (P = .011) in malignant CMTs. Our results demonstrate that TRPM7 is expressed in CMTs and that its expression is positively correlated with clinicopathological parameters. Thus, TRPM7 was assumed to be a potential prognostic factor for CMTs. Blackwell Publishing Ltd 2021-05-04 2021-09 /pmc/articles/PMC8453503/ /pubmed/33617107 http://dx.doi.org/10.1111/vco.12689 Text en © 2021 The Authors. Veterinary and Comparative Oncology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Lee, Seulji Lee, Sungin Kim, Wan Hee Expression and prognostic value of TRPM7 in canine mammary tumours |
title | Expression and prognostic value of TRPM7 in canine mammary tumours |
title_full | Expression and prognostic value of TRPM7 in canine mammary tumours |
title_fullStr | Expression and prognostic value of TRPM7 in canine mammary tumours |
title_full_unstemmed | Expression and prognostic value of TRPM7 in canine mammary tumours |
title_short | Expression and prognostic value of TRPM7 in canine mammary tumours |
title_sort | expression and prognostic value of trpm7 in canine mammary tumours |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453503/ https://www.ncbi.nlm.nih.gov/pubmed/33617107 http://dx.doi.org/10.1111/vco.12689 |
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