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The effect of equal fluoride concentrations in silver diamine fluoride and potassium fluoride on demineralized dentin during pH‐cycling: chemical data

The actual contribution of silver in silver diamine fluoride (SDF) towards the anti‐demineralizing effect is unclear. This study compared the effects of single applications of three concentrations of fluoride (4.1%, 1.025%, 0.26% F(−)) in the form of SDF and potassium fluoride (KF) on demineralized...

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Autores principales: Alhothali, Marwa, Exterkate, Rob, Lagerweij, Maxim, Buijs, Mark, van Loveren, Cor, van Strijp, Guus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453573/
https://www.ncbi.nlm.nih.gov/pubmed/33955578
http://dx.doi.org/10.1111/eos.12789
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author Alhothali, Marwa
Exterkate, Rob
Lagerweij, Maxim
Buijs, Mark
van Loveren, Cor
van Strijp, Guus
author_facet Alhothali, Marwa
Exterkate, Rob
Lagerweij, Maxim
Buijs, Mark
van Loveren, Cor
van Strijp, Guus
author_sort Alhothali, Marwa
collection PubMed
description The actual contribution of silver in silver diamine fluoride (SDF) towards the anti‐demineralizing effect is unclear. This study compared the effects of single applications of three concentrations of fluoride (4.1%, 1.025%, 0.26% F(−)) in the form of SDF and potassium fluoride (KF) on demineralized dentin in a 15‐day non‐microbial pH‐cycling model. Calcium loss and uptake in de‐ and remineralization buffers were analyzed daily. Fluoride release in both buffers was analyzed on days 1, 2, 3, and 8. The net calcium results of de‐ and remineralization cycles revealed dose‐response protection without significant differences between equal fluoride concentrations of SDF and KF. In the demineralization cycles, all fluoride treatments, except KF 0.26% F(−), significantly inhibited demineralization, with KF 4.1% F(−) being the most effective. In the remineralization cycles, remineralization was enhanced in all fluoride concentration groups in a dose‐response manner with no difference between similar fluoride concentrations of SDF and KF. Daily fluoride effects were constant throughout the experiment. Fluoride analysis revealed statistically significant differences in fluoride release between the treatments on day 1 that diminished on days 2 and 3. The non‐microbial model showed no differences between SDF and KF in inhibiting demineralization and enhancing remineralization of dentin lesions.
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spelling pubmed-84535732021-09-27 The effect of equal fluoride concentrations in silver diamine fluoride and potassium fluoride on demineralized dentin during pH‐cycling: chemical data Alhothali, Marwa Exterkate, Rob Lagerweij, Maxim Buijs, Mark van Loveren, Cor van Strijp, Guus Eur J Oral Sci Original Articles The actual contribution of silver in silver diamine fluoride (SDF) towards the anti‐demineralizing effect is unclear. This study compared the effects of single applications of three concentrations of fluoride (4.1%, 1.025%, 0.26% F(−)) in the form of SDF and potassium fluoride (KF) on demineralized dentin in a 15‐day non‐microbial pH‐cycling model. Calcium loss and uptake in de‐ and remineralization buffers were analyzed daily. Fluoride release in both buffers was analyzed on days 1, 2, 3, and 8. The net calcium results of de‐ and remineralization cycles revealed dose‐response protection without significant differences between equal fluoride concentrations of SDF and KF. In the demineralization cycles, all fluoride treatments, except KF 0.26% F(−), significantly inhibited demineralization, with KF 4.1% F(−) being the most effective. In the remineralization cycles, remineralization was enhanced in all fluoride concentration groups in a dose‐response manner with no difference between similar fluoride concentrations of SDF and KF. Daily fluoride effects were constant throughout the experiment. Fluoride analysis revealed statistically significant differences in fluoride release between the treatments on day 1 that diminished on days 2 and 3. The non‐microbial model showed no differences between SDF and KF in inhibiting demineralization and enhancing remineralization of dentin lesions. John Wiley and Sons Inc. 2021-05-06 2021-08 /pmc/articles/PMC8453573/ /pubmed/33955578 http://dx.doi.org/10.1111/eos.12789 Text en © 2021 The Authors. European Journal of Oral Sciences published by John Wiley & Sons Ltd on behalf of Scandinavian Division of the International Association for Dental Research https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Alhothali, Marwa
Exterkate, Rob
Lagerweij, Maxim
Buijs, Mark
van Loveren, Cor
van Strijp, Guus
The effect of equal fluoride concentrations in silver diamine fluoride and potassium fluoride on demineralized dentin during pH‐cycling: chemical data
title The effect of equal fluoride concentrations in silver diamine fluoride and potassium fluoride on demineralized dentin during pH‐cycling: chemical data
title_full The effect of equal fluoride concentrations in silver diamine fluoride and potassium fluoride on demineralized dentin during pH‐cycling: chemical data
title_fullStr The effect of equal fluoride concentrations in silver diamine fluoride and potassium fluoride on demineralized dentin during pH‐cycling: chemical data
title_full_unstemmed The effect of equal fluoride concentrations in silver diamine fluoride and potassium fluoride on demineralized dentin during pH‐cycling: chemical data
title_short The effect of equal fluoride concentrations in silver diamine fluoride and potassium fluoride on demineralized dentin during pH‐cycling: chemical data
title_sort effect of equal fluoride concentrations in silver diamine fluoride and potassium fluoride on demineralized dentin during ph‐cycling: chemical data
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453573/
https://www.ncbi.nlm.nih.gov/pubmed/33955578
http://dx.doi.org/10.1111/eos.12789
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