Cargando…

Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment

BACKGROUND: Most people who begin statins abandon them, most commonly because of side effects. OBJECTIVES: The purpose of this study was to assess daily symptom scores on statin, placebo, and no treatment in participants who had abandoned statins. METHODS: Participants received 12 1-month medication...

Descripción completa

Detalles Bibliográficos
Autores principales:	Howard, James P., Wood, Frances A., Finegold, Judith A., Nowbar, Alexandra N., Thompson, David M., Arnold, Ahran D., Rajkumar, Christopher A., Connolly, Susan, Cegla, Jaimini, Stride, Chris, Sever, Peter, Norton, Christine, Thom, Simon A.M., Shun-Shin, Matthew J., Francis, Darrel P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Biomedical 2021
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453640/ https://www.ncbi.nlm.nih.gov/pubmed/34531021 http://dx.doi.org/10.1016/j.jacc.2021.07.022

Ejemplares similares

2014 Global geographic analysis of mortality from ischaemic heart disease by country, age and income: Statistics from World Health Organisation and United Nations
por: Nowbar, Alexandra N., et al.
Publicado: (2014)

The Placebo-Controlled Effect of Percutaneous Coronary Intervention on Exercise Induced Changes in Anti-Malondialdehyde-LDL Antibody Levels in Stable Coronary Artery Disease: A Substudy of the ORBITA Trial
por: Hartley, Adam, et al.
Publicado: (2021)

Mortality from ischaemic heart disease by country, region, and age: Statistics from World Health Organisation and United Nations()
por: Finegold, Judith A., et al.
Publicado: (2013)

Randomized Blinded Placebo-Controlled Trials of Renal Sympathetic Denervation for Hypertension: A Meta-Analysis
por: Ahmad, Yousif, et al.
Publicado: (2022)

Frequency of discrepancies in retracted clinical trial reports versus unretracted reports: blinded case-control study
por: Cole, Graham D, et al.
Publicado: (2015)

Quality of Life Assessment in Trials of Revascularization for Chronic Stable Angina: Insights from ORBITA and the Implications of Blinding
por: Nowbar, Alexandra N, et al.
Publicado: (2021)

Statin tolerability: In defence of placebo-controlled trials
por: Tobert, Jonathan A, et al.
Publicado: (2015)

Cardiopulmonary exercise testing and efficacy of percutaneous coronary intervention: a substudy of the ORBITA trial( )
por: Ganesananthan, Sashiananthan, et al.
Publicado: (2022)

Lp(a): When and how to measure it
por: Cegla, Jaimini, et al.
Publicado: (2020)

Mortality From Ischemic Heart Disease: Analysis of Data From the World Health Organization and Coronary Artery Disease Risk Factors From NCD Risk Factor Collaboration
por: Nowbar, Alexandra N., et al.
Publicado: (2019)

Therapeutic options for syncope: a meta-analysis of trials with and without placebo control
por: Kaza, N, et al.
Publicado: (2023)

Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease: A Meta-Analysis of Randomized Controlled Trials
por: Chacko, Liza, et al.
Publicado: (2020)

Quantification of Survival Gain From Cardiac Resynchronization Therapy: Nonlinear Growth With Time, and Greater Gain in Low-Risk Patients, Make Raw Trial Data an Underestimate of Real-World Behavior
por: Finegold, Judith A., et al.
Publicado: (2013)

Placebo‐controlled crossover assessment of mecasermin for the treatment of Rett syndrome
por: O'Leary, Heather M., et al.
Publicado: (2018)

A Case Series Assessing the Effects of Lomitapide on Carotid Intima-Media Thickness in Adult Patients with Homozygous Familial Hypercholesterolaemia in a Real-World Setting
por: Blom, Dirk J., et al.
Publicado: (2022)

Systematic review of genuine versus spurious side-effects of beta-blockers in heart failure using placebo control: Recommendations for patient information()()
por: Barron, Anthony J., et al.
Publicado: (2013)

Cost-effectiveness analysis of percutaneous coronary intervention for single-vessel coronary artery disease: an economic evaluation of the ORBITA trial
por: McCreanor, Victoria, et al.
Publicado: (2021)

Study protocol for statin web-based investigation of side effects (StatinWISE): a series of randomised controlled N-of-1 trials comparing atorvastatin and placebo in UK primary care
por: Herrett, Emily, et al.
Publicado: (2017)

Shared Decisions: A Qualitative Study on Clinician and Patient Perspectives on Statin Therapy and Statin‐Associated Side Effects
por: Ahmed, Sarah T., et al.
Publicado: (2020)

Prolonged remission from hepatic encephalopathy with rifaximin: results of a placebo crossover analysis
por: Bajaj, J S, et al.
Publicado: (2015)

Effect of atorvastatin on muscle symptoms in coronary heart disease patients with self-perceived statin muscle side effects: a randomized, double-blinded crossover trial
por: Kristiansen, Oscar, et al.
Publicado: (2020)

Dobutamine Stress Echocardiography Ischemia as a Predictor of the Placebo-Controlled Efficacy of Percutaneous Coronary Intervention in Stable Coronary Artery Disease: The Stress Echocardiography–Stratified Analysis of ORBITA
por: Al-Lamee, Rasha K., et al.
Publicado: (2019)

Effects of combined statin and ACE inhibitor therapy on endothelial function and blood pressure in essential hypertension - a randomised double-blind, placebo controlled crossover study
por: Ruszkowski, Piotr, et al.
Publicado: (2019)

Randomized, Placebo-controlled Crossover Study of Dalfampridine Extended-release in Transverse Myelitis
por: Schwartz, Kateryna, et al.
Publicado: (2017)

Placebo-Controlled Efficacy of Percutaneous Coronary Intervention for Focal and Diffuse Patterns of Stable Coronary Artery Disease
por: Rajkumar, Christopher A., et al.
Publicado: (2021)

Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasia
por: Thompson, K. P., et al.
Publicado: (2022)

Discrepancies in autologous bone marrow stem cell trials and enhancement of ejection fraction (DAMASCENE): weighted regression and meta-analysis
por: Nowbar, Alexandra N, et al.
Publicado: (2014)

Distribution of lifespan gain from primary prevention intervention
por: Finegold, Judith A, et al.
Publicado: (2016)

The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection
por: Koch, Marion, et al.
Publicado: (2019)

The use of whole blood capillary samples to measure 15 analytes for a home-collect biochemistry service during the SARS-CoV-2 pandemic: A proposed model from North West London Pathology
por: Ansari, Saleem, et al.
Publicado: (2021)

Physicians’ Experiences as Patients with Statin Side Effects: A Case Series
por: Koslik, Hayley J., et al.
Publicado: (2017)

Difficulty in detecting discrepancies in a clinical trial report: 260-reader evaluation
por: Cole, Graham D, et al.
Publicado: (2015)

Efficient assessment of efficacy in post-traumatic peripheral neuropathic pain patients: pregabalin in a randomized, placebo-controlled, crossover study
por: Jenkins, Tim M, et al.
Publicado: (2012)

Tiotropium treatment for bronchiectasis: a randomised, placebo-controlled, crossover trial
por: Jayaram, Lata, et al.
Publicado: (2022)

Quality of life and paracetamol in advanced dementia (Q-PID): protocol of a randomised double-blind placebo-controlled crossover trial
por: van Dam, Paulien H., et al.
Publicado: (2018)

The effect of Sailuotong (SLT) on neurocognitive and cardiovascular function in healthy adults: a randomised, double-blind, placebo controlled crossover pilot trial
por: Steiner, Genevieve Z., et al.
Publicado: (2016)

Randomised, double-blind, placebo-controlled crossover study of single-dose guanfacine in unilateral neglect following stroke
por: Dalmaijer, Edwin S, et al.
Publicado: (2018)

Optimizing atrio‐ventricular delay in pacemakers using potentially implantable physiological biomarkers
por: Keene, Daniel, et al.
Publicado: (2022)

Effect of Study Design on the Reported Effect of Cardiac Resynchronization Therapy (CRT) on Quantitative Physiological Measures: Stratified Meta‐Analysis in Narrow‐QRS Heart Failure and Implications for Planning Future Studies
por: Jabbour, Richard J., et al.
Publicado: (2015)

Cardiac Effects of a Single Dose of Pimobendan in Cats With Hypertrophic Cardiomyopathy; A Randomized, Placebo-Controlled, Crossover Study
por: Oldach, Maureen S., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_oe8spuecoem84ocqpiogup12te