Sequence‐Selective Covalent CaaX‐Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling

Oncogenic Ras proteins are implicated in the most common life‐threatening cancers. Despite intense research over the past two decades, the progress towards small‐molecule inhibitors has been limited. One reason for this failure is that Ras proteins interact with their effectors only via protein‐prot...

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Detalles Bibliográficos
Autores principales: Franz, Matthias, Mörchen, Britta, Degenhart, Carsten, Gülden, Daniel, Shkura, Oleksandr, Wolters, Dirk, Koch, Uwe, Klebl, Bert, Stoll, Raphael, Helfrich, Iris, Scherkenbeck, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453727/
https://www.ncbi.nlm.nih.gov/pubmed/33899342
http://dx.doi.org/10.1002/cmdc.202100167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453727/
https://www.ncbi.nlm.nih.gov/pubmed/33899342
http://dx.doi.org/10.1002/cmdc.202100167

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