NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems

To overcome COVID-19 long-term consequences, one possible approach is to control inflammasomes activation, because SARS-CoV-2 can induce humoral and cellular immune responses. In this opinion article we hypothesized that if it is proven with convincing and unmistakable evidence that firstly, SARS-Co...

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Detalles Bibliográficos
Autores principales: Bazrafkan, Mahshid, Hosseini, Elham, Nazari, Mahboobeh, Amorim, Christiani Andrade, Sadeghi, Mohammad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453780/
https://www.ncbi.nlm.nih.gov/pubmed/34563758
http://dx.doi.org/10.1016/j.jri.2021.103427
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author Bazrafkan, Mahshid
Hosseini, Elham
Nazari, Mahboobeh
Amorim, Christiani Andrade
Sadeghi, Mohammad Reza
author_facet Bazrafkan, Mahshid
Hosseini, Elham
Nazari, Mahboobeh
Amorim, Christiani Andrade
Sadeghi, Mohammad Reza
author_sort Bazrafkan, Mahshid
collection PubMed
description To overcome COVID-19 long-term consequences, one possible approach is to control inflammasomes activation, because SARS-CoV-2 can induce humoral and cellular immune responses. In this opinion article we hypothesized that if it is proven with convincing and unmistakable evidence that firstly, SARS-CoV-2 can enter cells and damage them through its common receptors in the reproductive tissues, and secondly, inflammasome pathway activation is responsible for the damages caused, then the inflammasome inhibitors might be considered as suitable candidates in preventing the pathological effects on the germ cells and reproductive tissues and subsequent fertility.
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spelling pubmed-84537802021-09-21 NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems Bazrafkan, Mahshid Hosseini, Elham Nazari, Mahboobeh Amorim, Christiani Andrade Sadeghi, Mohammad Reza J Reprod Immunol Article To overcome COVID-19 long-term consequences, one possible approach is to control inflammasomes activation, because SARS-CoV-2 can induce humoral and cellular immune responses. In this opinion article we hypothesized that if it is proven with convincing and unmistakable evidence that firstly, SARS-CoV-2 can enter cells and damage them through its common receptors in the reproductive tissues, and secondly, inflammasome pathway activation is responsible for the damages caused, then the inflammasome inhibitors might be considered as suitable candidates in preventing the pathological effects on the germ cells and reproductive tissues and subsequent fertility. Elsevier B.V. 2021-11 2021-09-21 /pmc/articles/PMC8453780/ /pubmed/34563758 http://dx.doi.org/10.1016/j.jri.2021.103427 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bazrafkan, Mahshid
Hosseini, Elham
Nazari, Mahboobeh
Amorim, Christiani Andrade
Sadeghi, Mohammad Reza
NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems
title NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems
title_full NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems
title_fullStr NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems
title_full_unstemmed NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems
title_short NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems
title_sort nlrp3 inflammasome: a joint, potential therapeutic target in management of covid-19 and fertility problems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453780/
https://www.ncbi.nlm.nih.gov/pubmed/34563758
http://dx.doi.org/10.1016/j.jri.2021.103427
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