Exogenous insulin antibody syndrome treated with plasma exchange after an incomplete response to immunosuppressive therapy

A 43‐year‐old man with a 23‐year history of type II diabetes presented with uncontrolled hyperglycemia with frequent episodes of ketoacidosis. He was diagnosed with exogenous insulin antibody syndrome, and received high‐dose methylprednisolone to treat insulin resistance. Ketoacidosis relapsed 2 yea...

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Detalles Bibliográficos
Autores principales: Zhuang, Yuan, Wei, Xudong, Yu, Yang, Wang, Deqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453898/
https://www.ncbi.nlm.nih.gov/pubmed/34013991
http://dx.doi.org/10.1002/jca.21905
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author Zhuang, Yuan
Wei, Xudong
Yu, Yang
Wang, Deqing
author_facet Zhuang, Yuan
Wei, Xudong
Yu, Yang
Wang, Deqing
author_sort Zhuang, Yuan
collection PubMed
description A 43‐year‐old man with a 23‐year history of type II diabetes presented with uncontrolled hyperglycemia with frequent episodes of ketoacidosis. He was diagnosed with exogenous insulin antibody syndrome, and received high‐dose methylprednisolone to treat insulin resistance. Ketoacidosis relapsed 2 years later, and the patient showed an incomplete response to glucocorticoids. We decided to administer therapeutic plasma exchange, which resulted in rapid lowering of the daily insulin requirement and improved glycemic control.
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spelling pubmed-84538982021-09-27 Exogenous insulin antibody syndrome treated with plasma exchange after an incomplete response to immunosuppressive therapy Zhuang, Yuan Wei, Xudong Yu, Yang Wang, Deqing J Clin Apher Case Reports A 43‐year‐old man with a 23‐year history of type II diabetes presented with uncontrolled hyperglycemia with frequent episodes of ketoacidosis. He was diagnosed with exogenous insulin antibody syndrome, and received high‐dose methylprednisolone to treat insulin resistance. Ketoacidosis relapsed 2 years later, and the patient showed an incomplete response to glucocorticoids. We decided to administer therapeutic plasma exchange, which resulted in rapid lowering of the daily insulin requirement and improved glycemic control. John Wiley & Sons, Inc. 2021-05-20 2021-08 /pmc/articles/PMC8453898/ /pubmed/34013991 http://dx.doi.org/10.1002/jca.21905 Text en © 2021 The Authors. Journal of Clinical Apheresis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Zhuang, Yuan
Wei, Xudong
Yu, Yang
Wang, Deqing
Exogenous insulin antibody syndrome treated with plasma exchange after an incomplete response to immunosuppressive therapy
title Exogenous insulin antibody syndrome treated with plasma exchange after an incomplete response to immunosuppressive therapy
title_full Exogenous insulin antibody syndrome treated with plasma exchange after an incomplete response to immunosuppressive therapy
title_fullStr Exogenous insulin antibody syndrome treated with plasma exchange after an incomplete response to immunosuppressive therapy
title_full_unstemmed Exogenous insulin antibody syndrome treated with plasma exchange after an incomplete response to immunosuppressive therapy
title_short Exogenous insulin antibody syndrome treated with plasma exchange after an incomplete response to immunosuppressive therapy
title_sort exogenous insulin antibody syndrome treated with plasma exchange after an incomplete response to immunosuppressive therapy
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453898/
https://www.ncbi.nlm.nih.gov/pubmed/34013991
http://dx.doi.org/10.1002/jca.21905
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AT yuyang exogenousinsulinantibodysyndrometreatedwithplasmaexchangeafteranincompleteresponsetoimmunosuppressivetherapy
AT wangdeqing exogenousinsulinantibodysyndrometreatedwithplasmaexchangeafteranincompleteresponsetoimmunosuppressivetherapy

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