Neurodegeneration in Hepatic and Neurologic Wilson’s Disease

Clinical presentation of Wilson disease (WD) includes hepatic and neurologic manifestations. This study compares subcortical brain regions by magnetic resonance imaging in patients with WD and without neurological symptoms. Distinct atrophy affecting the basal ganglia, accumbens, and hippocampus was...

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Detalles Bibliográficos
Autores principales: Viveiros, André, Beliveau, Vincent, Panzer, Marlene, Schaefer, Benedikt, Glodny, Bernhard, Henninger, Benjamin, Tilg, Herbert, Zoller, Heinz, Scherfler, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Clinical Observations in Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453945/
https://www.ncbi.nlm.nih.gov/pubmed/33316133
http://dx.doi.org/10.1002/hep.31681
Descripción
Sumario:Clinical presentation of Wilson disease (WD) includes hepatic and neurologic manifestations. This study compares subcortical brain regions by magnetic resonance imaging in patients with WD and without neurological symptoms. Distinct atrophy affecting the basal ganglia, accumbens, and hippocampus was present in neurological WD. Cerebellar atrophy was observed in hepatic WD without neurological symptoms.

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