Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus

We report here the synthesis, purification, and characterization of mono- and di-fatty acyl conjugates of remdesivir (RDV) and their in vitro antiviral activity against SAR-CoV-2, an Ebola virus transcription- and replication-competent virus-like particle (trVLP) system, and infectious Ebola virus....

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Detalles Bibliográficos
Autores principales: El-Sayed, Naglaa Salem, Jureka, Alexander S., Edwards, Megan R., Lohan, Sandeep, Williams, Caroline G., Keiser, Patrick T., Davey, Robert A., Totonchy, Jennifer, Tiwari, Rakesh K., Basler, Christopher F., Parang, Keykavous
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454092/
https://www.ncbi.nlm.nih.gov/pubmed/34583312
http://dx.doi.org/10.1016/j.ejmech.2021.113862

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