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An insertion variant of MGMT disrupts a STAT1 binding site and confers susceptibility to glioma

BACKGROUND: O(6)-methylguanine-DNA methyltransferase (MGMT) is a pivotal enzyme for repairing DNA alkylation damage. Epigenetic modification of MGMT has been well known as a promising prognostic biomarker for glioma. However, the significance of genetic variations of MGMT in glioma carcinogenesis ha...

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Detalles Bibliográficos
Autores principales:	Huang, Liming, Xu, Wenshen, Yan, Danfang, Shi, Xi, You, Xin, Xu, Jiaqi, You, Pingping, Ke, Yuanyuan, Dai, Lian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454171/ https://www.ncbi.nlm.nih.gov/pubmed/34544433 http://dx.doi.org/10.1186/s12935-021-02211-4

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