Cargando…

Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in Mice

The ongoing global pandemic of coronavirus disease 2019 (COVID-19) calls for an urgent development of effective and safe prophylactic and therapeutic measures. The spike (S) glycoprotein of severe acute respiratory syndrome-coronavirus (SARS-CoV-2) is a major immunogenic and protective protein and p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alamri, Sawsan S., Alluhaybi, Khalid A., Alhabbab, Rowa Y., Basabrain, Mohammad, Algaissi, Abdullah, Almahboub, Sarah, Alfaleh, Mohamed A., Abujamel, Turki S., Abdulaal, Wesam H., ElAssouli, M-Zaki, Alharbi, Rahaf H., Hassanain, Mazen, Hashem, Anwar M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454412/ https://www.ncbi.nlm.nih.gov/pubmed/34557174 http://dx.doi.org/10.3389/fmicb.2021.727455

Ejemplares similares

Cellular and Humoral Immunogenicity of a Candidate DNA Vaccine Expressing SARS-CoV-2 Spike Subunit 1
por: Alluhaybi, Khalid A., et al.
Publicado: (2021)

Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients
por: Hashem, Anwar M., et al.
Publicado: (2020)

SARS-CoV-2 S1 and N-based serological assays reveal rapid seroconversion and induction of specific antibody response in COVID-19 patients
por: Algaissi, Abdullah, et al.
Publicado: (2020)

Evaluation of Neutralizing Antibodies Against Highly Pathogenic Coronaviruses: A Detailed Protocol for a Rapid Evaluation of Neutralizing Antibodies Using Vesicular Stomatitis Virus Pseudovirus-Based Assay
por: Almahboub, Sarah A., et al.
Publicado: (2020)

Amplifying Lateral Flow Assay Signals for Rapid Detection of COVID‐19 Specific Antibodies
por: Alhabbab, Rowa Y., et al.
Publicado: (2022)

Performance of Commercially Available Rapid Serological Assays for the Detection of SARS-CoV-2 Antibodies
por: Hashem, Anwar M., et al.
Publicado: (2020)

Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia
por: Alhabbab, Rowa Y., et al.
Publicado: (2021)

The importance of combining serological testing with RT-PCR assays for efficient detection of COVID-19 and higher diagnostic accuracy
por: Alamri, Sawsan S., et al.
Publicado: (2023)

Preparedness and response to COVID-19 in Saudi Arabia: Building on MERS experience
por: Algaissi, Abdullah A., et al.
Publicado: (2020)

Seroprevalence of MERS-CoV in healthy adults in western Saudi Arabia, 2011–2016
por: Degnah, Afnan A., et al.
Publicado: (2020)

Iron Chelation Reduces DNA Damage in Sickle Cell Anemia
por: Al-Khateeb, Rawan S., et al.
Publicado: (2021)

Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells
por: Alhabbab, Rowa Y.
Publicado: (2020)

Lateral Flow Immunoassays for Detecting Viral Infectious Antigens and Antibodies
por: Alhabbab, Rowa Y.
Publicado: (2022)

Economical and Easily Obtainable Tools to Manually Develop Lateral Flow Immunoassay Strips
por: Alhabbab, Rowa Y.
Publicado: (2023)

Genotoxicity of Air Borne Particulates Assessed by Comet and the Salmonella Mutagenicity Test in Jeddah, Saudi Arabia
por: ElAssouli, Sufian M., et al.
Publicado: (2007)

Apigenin Loaded Lipoid–PLGA–TPGS Nanoparticles for Colon Cancer Therapy: Characterization, Sustained Release, Cytotoxicity, and Apoptosis Pathways
por: Alfaleh, Mohamed A., et al.
Publicado: (2022)

Mouth rinses efficacy on salivary SARS‐CoV‐2 viral load: A randomized clinical trial
por: Alzahrani, Manar M., et al.
Publicado: (2022)

Construction of VSVΔ51M oncolytic virus expressing human interleukin-12
por: Abdulal, Rwaa H., et al.
Publicado: (2023)

Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike Protein
por: Al-amri, Sawsan S., et al.
Publicado: (2017)

Therapeutic use of chloroquine and hydroxychloroquine in COVID-19 and other viral infections: A narrative review
por: Hashem, Anwar M., et al.
Publicado: (2020)

Molecular Evidence of Influenza A Virus Circulation in African Dromedary Camels Imported to Saudi Arabia, 2017–2018
por: Alghamdi, Abdulaziz, et al.
Publicado: (2019)

David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors
por: Alfaleh, Mohamed A., et al.
Publicado: (2022)

Different Alterations in Gut Microbiota between Bifidobacterium longum and Fecal Microbiota Transplantation Treatments in Propionic Acid Rat Model of Autism
por: Abujamel, Turki S., et al.
Publicado: (2022)

Evaluating the therapeutic efficacy, tolerability, and safety of an aqueous extract of Costus speciosus rhizome in acute pharyngitis and acute tonsillitis: A pilot study
por: Bakhsh, Zainab A., et al.
Publicado: (2015)

Purification and characterization of α-amylase from Trichoderma pseudokoningii
por: Abdulaal, Wesam H.
Publicado: (2018)

Purification and characterization of cysteine protease from miswak Salvadora persica
por: Abdulaal, Wesam H.
Publicado: (2018)

An Overview of the Performance Improvement Initiatives by the Ministry of Health in the Kingdom of Saudi Arabia
por: Hassanain, Mazen
Publicado: (2017)

Overlapping variants in the blood, tissues and cell lines for patients with intracranial meningiomas are predominant in stem cell-related genes
por: Hussein, Deema, et al.
Publicado: (2020)

Evaluation of MERS-CoV Neutralizing Antibodies in Sera Using Live Virus Microneutralization Assay
por: Algaissi, Abdullah, et al.
Publicado: (2019)

Side Effects of COVID-19 Pfizer-BioNTech mRNA Vaccine in Children Aged 12–18 Years in Saudi Arabia
por: Alamer, Edrous, et al.
Publicado: (2021)

Efflux pump inhibitors (EPIs) as new antimicrobial agents against Pseudomonas aeruginosa
por: Askoura, Momen, et al.
Publicado: (2011)

Using Psychophysiological Measures to Examine the Temporal Profile of Verbal Humor Elicitation
por: Fiacconi, Chris M., et al.
Publicado: (2015)

Norovirus P Particle Efficiently Elicits Innate, Humoral and Cellular Immunity
por: Fang, Hao, et al.
Publicado: (2013)

DNA Vaccines Against Mycoplasma Elicit Humoral Immune Responses in Ostriches
por: Wium, Martha, et al.
Publicado: (2019)

Development and validation of different indirect ELISAs for MERS-CoV serological testing
por: Hashem, Anwar M., et al.
Publicado: (2019)

Laparoscopic Versus Open Appendectomy
por: Ali, Safiyya M., et al.
Publicado: (2011)

Correction: Norovirus P Particle Efficiently Elicits Innate, Humoral and Cellular Immunity
por: Fang, Hao, et al.
Publicado: (2014)

Institutional Research Evaluation Model (IREM): A framework for measuring organizational research trends and impact and its application in medical academia in Saudi Arabia
por: Hassanain, Mazen, et al.
Publicado: (2016)

Livelihood activities, human mobility, and risk of malaria infection in elimination settings: a case–control study
por: Abdalal, Shaymaa A., et al.
Publicado: (2023)

Intranasal Immunization with Pressure Inactivated Avian Influenza Elicits Cellular and Humoral Responses in Mice
por: Barroso, Shana P. C., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_qcml23gjgj961uvhuiljj1ba0t