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Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis
The most common neurological manifestation of eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is mononeuritis multiplex caused by small-vessel vasculitis. In contrast, central nervous system involvement is rare. Among EGPA-associated central nervous syst...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454454/ https://www.ncbi.nlm.nih.gov/pubmed/34544704 http://dx.doi.org/10.1136/bcr-2021-243395 |
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author | Shiraishi, Wataru Tsujimoto, Yoshitaka Shiraishi, Tomoko |
author_facet | Shiraishi, Wataru Tsujimoto, Yoshitaka Shiraishi, Tomoko |
author_sort | Shiraishi, Wataru |
collection | PubMed |
description | The most common neurological manifestation of eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is mononeuritis multiplex caused by small-vessel vasculitis. In contrast, central nervous system involvement is rare. Among EGPA-associated central nervous system disorders, there are only a few reported cases of hypertrophic pachymeningitis (HP). Here, we report a patient with EGPA with headache and ophthalmoplegia who presented with HP and had a dural biopsy. The biopsy specimen showed lymphocytic inflammatory cell infiltration without EGPA-specific findings, that is, eosinophilic infiltration, granuloma or angiitis. To the best of our knowledge, there are no previous reports of EGPA-associated HP pathology. Here, we report the first case presentation of a patient with EGPA-associated HP with pathological findings. |
format | Online Article Text |
id | pubmed-8454454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-84544542021-10-07 Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis Shiraishi, Wataru Tsujimoto, Yoshitaka Shiraishi, Tomoko BMJ Case Rep Case Report The most common neurological manifestation of eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is mononeuritis multiplex caused by small-vessel vasculitis. In contrast, central nervous system involvement is rare. Among EGPA-associated central nervous system disorders, there are only a few reported cases of hypertrophic pachymeningitis (HP). Here, we report a patient with EGPA with headache and ophthalmoplegia who presented with HP and had a dural biopsy. The biopsy specimen showed lymphocytic inflammatory cell infiltration without EGPA-specific findings, that is, eosinophilic infiltration, granuloma or angiitis. To the best of our knowledge, there are no previous reports of EGPA-associated HP pathology. Here, we report the first case presentation of a patient with EGPA-associated HP with pathological findings. BMJ Publishing Group 2021-09-20 /pmc/articles/PMC8454454/ /pubmed/34544704 http://dx.doi.org/10.1136/bcr-2021-243395 Text en © BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Case Report Shiraishi, Wataru Tsujimoto, Yoshitaka Shiraishi, Tomoko Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis |
title | Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis |
title_full | Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis |
title_fullStr | Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis |
title_full_unstemmed | Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis |
title_short | Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis |
title_sort | pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454454/ https://www.ncbi.nlm.nih.gov/pubmed/34544704 http://dx.doi.org/10.1136/bcr-2021-243395 |
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