Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male

We present a case of a human immunodeficiency virus–negative man with syphilitic meningovascular disease with subjacent involvement of brain parenchyma leading to a mass-forming inflammatory lesion that was pathologically distinct from a typical gumma. Syphilis was diagnosed after tissue obtained fr...

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Autores principales: Pham, Khanh, Gottesdiener, Lee, Simon, Matthew S, Trzebucki, Alex, Maldarelli, Grace A, Cisse, Babacar, Lieberman, Joshua, DeHaan, Elliot, Pisapia, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Novel ID Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454516/
https://www.ncbi.nlm.nih.gov/pubmed/34557566
http://dx.doi.org/10.1093/ofid/ofab455
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author Pham, Khanh
Gottesdiener, Lee
Simon, Matthew S
Trzebucki, Alex
Maldarelli, Grace A
Cisse, Babacar
Lieberman, Joshua
DeHaan, Elliot
Pisapia, David
author_facet Pham, Khanh
Gottesdiener, Lee
Simon, Matthew S
Trzebucki, Alex
Maldarelli, Grace A
Cisse, Babacar
Lieberman, Joshua
DeHaan, Elliot
Pisapia, David
author_sort Pham, Khanh
collection PubMed
description We present a case of a human immunodeficiency virus–negative man with syphilitic meningovascular disease with subjacent involvement of brain parenchyma leading to a mass-forming inflammatory lesion that was pathologically distinct from a typical gumma. Syphilis was diagnosed after tissue obtained from a brain biopsy demonstrated spirochetes consistent with Treponema pallidum and confirmed by 16S ribosomal RNA sequencing.
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spelling pubmed-84545162021-09-22 Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male Pham, Khanh Gottesdiener, Lee Simon, Matthew S Trzebucki, Alex Maldarelli, Grace A Cisse, Babacar Lieberman, Joshua DeHaan, Elliot Pisapia, David Open Forum Infect Dis Novel ID Cases We present a case of a human immunodeficiency virus–negative man with syphilitic meningovascular disease with subjacent involvement of brain parenchyma leading to a mass-forming inflammatory lesion that was pathologically distinct from a typical gumma. Syphilis was diagnosed after tissue obtained from a brain biopsy demonstrated spirochetes consistent with Treponema pallidum and confirmed by 16S ribosomal RNA sequencing. Oxford University Press 2021-08-31 /pmc/articles/PMC8454516/ /pubmed/34557566 http://dx.doi.org/10.1093/ofid/ofab455 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Novel ID Cases
Pham, Khanh
Gottesdiener, Lee
Simon, Matthew S
Trzebucki, Alex
Maldarelli, Grace A
Cisse, Babacar
Lieberman, Joshua
DeHaan, Elliot
Pisapia, David
Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male
title Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male
title_full Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male
title_fullStr Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male
title_full_unstemmed Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male
title_short Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male
title_sort meningovascular syphilis presenting as a brain mass in an immunocompetent male
topic Novel ID Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454516/
https://www.ncbi.nlm.nih.gov/pubmed/34557566
http://dx.doi.org/10.1093/ofid/ofab455
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