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Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update

Infertility is one of the most common non-communicable diseases, affecting both men and women equally. Ovarian reserve, the number of primordial follicles in the ovaries is believed to be the most important determinants for female fertility. Anti-Müllerian hormone (AMH) secreted from granulosa cells...

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Autores principales: Xu, Huiyu, Zhang, Mengqian, Zhang, Hongxian, Alpadi, Kannan, Wang, Lina, Li, Rong, Qiao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454570/
https://www.ncbi.nlm.nih.gov/pubmed/34557745
http://dx.doi.org/10.1016/j.xinn.2021.100091
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author Xu, Huiyu
Zhang, Mengqian
Zhang, Hongxian
Alpadi, Kannan
Wang, Lina
Li, Rong
Qiao, Jie
author_facet Xu, Huiyu
Zhang, Mengqian
Zhang, Hongxian
Alpadi, Kannan
Wang, Lina
Li, Rong
Qiao, Jie
author_sort Xu, Huiyu
collection PubMed
description Infertility is one of the most common non-communicable diseases, affecting both men and women equally. Ovarian reserve, the number of primordial follicles in the ovaries is believed to be the most important determinants for female fertility. Anti-Müllerian hormone (AMH) secreted from granulosa cells of growing follicles is recognized as the most important biomarker for ovarian reserve. Ovarian reserve models have been developed using AMH and other hormonal indicators, thus childbearing plans and reproductive choices could be arranged by women. In assisted reproductive technology cycles, measurement of AMH helps to predict ovarian response and guide recombinant follicle-stimulating hormone dosing in women. Serum AMH level is increasingly being recognized as a potential surrogate marker for polycystic ovarian morphology, one of the criteria for diagnosis of polycystic ovarian syndrome. AMH is also secreted by Sertoli cells of testes in men, and AMH measurements in the prediction of surgical sperm recovery rate in men have also been investigated. AMH levels are significantly higher in boys than in girls before puberty. Therefore, serum levels of AMH in combination with testosterone is used for the differential diagnosis of disorders of sex development, anorchia, non-obstructive azoospermia, and persistent Müllerian duct syndrome. Recently, serum AMH measurements have also been used in fertility preservation programs in oncofertility, screening for granulosa cell tumors, and prediction of menopause applications. In this review, we will focus on clinical application of AMH in fertility assessments for healthy men and women, as well as for cancer patients.
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spelling pubmed-84545702021-09-22 Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update Xu, Huiyu Zhang, Mengqian Zhang, Hongxian Alpadi, Kannan Wang, Lina Li, Rong Qiao, Jie Innovation (Camb) Review Infertility is one of the most common non-communicable diseases, affecting both men and women equally. Ovarian reserve, the number of primordial follicles in the ovaries is believed to be the most important determinants for female fertility. Anti-Müllerian hormone (AMH) secreted from granulosa cells of growing follicles is recognized as the most important biomarker for ovarian reserve. Ovarian reserve models have been developed using AMH and other hormonal indicators, thus childbearing plans and reproductive choices could be arranged by women. In assisted reproductive technology cycles, measurement of AMH helps to predict ovarian response and guide recombinant follicle-stimulating hormone dosing in women. Serum AMH level is increasingly being recognized as a potential surrogate marker for polycystic ovarian morphology, one of the criteria for diagnosis of polycystic ovarian syndrome. AMH is also secreted by Sertoli cells of testes in men, and AMH measurements in the prediction of surgical sperm recovery rate in men have also been investigated. AMH levels are significantly higher in boys than in girls before puberty. Therefore, serum levels of AMH in combination with testosterone is used for the differential diagnosis of disorders of sex development, anorchia, non-obstructive azoospermia, and persistent Müllerian duct syndrome. Recently, serum AMH measurements have also been used in fertility preservation programs in oncofertility, screening for granulosa cell tumors, and prediction of menopause applications. In this review, we will focus on clinical application of AMH in fertility assessments for healthy men and women, as well as for cancer patients. Elsevier 2021-02-09 /pmc/articles/PMC8454570/ /pubmed/34557745 http://dx.doi.org/10.1016/j.xinn.2021.100091 Text en © 2021. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Xu, Huiyu
Zhang, Mengqian
Zhang, Hongxian
Alpadi, Kannan
Wang, Lina
Li, Rong
Qiao, Jie
Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update
title Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update
title_full Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update
title_fullStr Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update
title_full_unstemmed Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update
title_short Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update
title_sort clinical applications of serum anti-müllerian hormone measurements in both males and females: an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454570/
https://www.ncbi.nlm.nih.gov/pubmed/34557745
http://dx.doi.org/10.1016/j.xinn.2021.100091
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