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Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies

The epithelial-to-mesenchymal transition (EMT), an embryonic program relaunched during wound healing and in pathological conditions such as fibrosis and cancer, continues to gain the attention of the research community, as testified by the exponential trend of publications since its discovery in the...

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Autor principal: Lovisa, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454779/
https://www.ncbi.nlm.nih.gov/pubmed/34557100
http://dx.doi.org/10.3389/fphar.2021.737570
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author Lovisa, Sara
author_facet Lovisa, Sara
author_sort Lovisa, Sara
collection PubMed
description The epithelial-to-mesenchymal transition (EMT), an embryonic program relaunched during wound healing and in pathological conditions such as fibrosis and cancer, continues to gain the attention of the research community, as testified by the exponential trend of publications since its discovery in the seventies. From the first description as a mesenchymal transformation, the concept of EMT has been substantially refined as an in-depth comprehension of its functional role has recently emerged thanks to the implementation of novel mouse models as well as the use of sophisticated mathematical modeling and bioinformatic analysis. Nevertheless, attempts to targeting EMT in fibrotic diseases are at their infancy and continue to pose several challenges. The aim of this mini review is to recapitulate the most recent concepts in the EMT field and to summarize the different strategies which have been exploited to target EMT in fibrotic disorders.
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spelling pubmed-84547792021-09-22 Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies Lovisa, Sara Front Pharmacol Pharmacology The epithelial-to-mesenchymal transition (EMT), an embryonic program relaunched during wound healing and in pathological conditions such as fibrosis and cancer, continues to gain the attention of the research community, as testified by the exponential trend of publications since its discovery in the seventies. From the first description as a mesenchymal transformation, the concept of EMT has been substantially refined as an in-depth comprehension of its functional role has recently emerged thanks to the implementation of novel mouse models as well as the use of sophisticated mathematical modeling and bioinformatic analysis. Nevertheless, attempts to targeting EMT in fibrotic diseases are at their infancy and continue to pose several challenges. The aim of this mini review is to recapitulate the most recent concepts in the EMT field and to summarize the different strategies which have been exploited to target EMT in fibrotic disorders. Frontiers Media S.A. 2021-09-07 /pmc/articles/PMC8454779/ /pubmed/34557100 http://dx.doi.org/10.3389/fphar.2021.737570 Text en Copyright © 2021 Lovisa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lovisa, Sara
Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies
title Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies
title_full Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies
title_fullStr Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies
title_full_unstemmed Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies
title_short Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies
title_sort epithelial-to-mesenchymal transition in fibrosis: concepts and targeting strategies
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454779/
https://www.ncbi.nlm.nih.gov/pubmed/34557100
http://dx.doi.org/10.3389/fphar.2021.737570
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