Cargando…

Nonequilibrium Green’s Functions for Functional Connectivity in the Brain

A theoretical framework describing the set of interactions between neurons in the brain, or functional connectivity, should include dynamical functions representing the propagation of signal from one neuron to another. Green’s functions and response functions are natural candidates for this but, whi...

Descripción completa

Detalles Bibliográficos
Autores principales: Randi, Francesco, Leifer, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454901/
https://www.ncbi.nlm.nih.gov/pubmed/33798383
http://dx.doi.org/10.1103/PhysRevLett.126.118102
Descripción
Sumario:A theoretical framework describing the set of interactions between neurons in the brain, or functional connectivity, should include dynamical functions representing the propagation of signal from one neuron to another. Green’s functions and response functions are natural candidates for this but, while they are conceptually very useful, they are usually defined only for linear time-translationally invariant systems. The brain, instead, behaves nonlinearly and in a time-dependent way. Here, we use nonequilibrium Green’s functions to describe the time-dependent functional connectivity of a continuous-variable network of neurons. We show how the connectivity is related to the measurable response functions, and provide two illustrative examples via numerical calculations, inspired from Caenorhabditis elegans.