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Comanagement With Nephrologist Care Is Associated With Fewer Cardiovascular Events Among Liver Transplant Recipients With Chronic Kidney Disease

BACKGROUND. Chronic kidney disease (CKD) is associated with cardiovascular (CV) events, a leading complication in liver transplant recipients (LTRs). Timely subspecialty care is associated with improved clinical outcomes in patients with CKD. This study sought to assess associations between nephrolo...

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Autores principales: Campbell, Patrick T., Kosirog, Megan, Aghaulor, Blessing, Gregory, Dyanna, Pine, Stewart, Daud, Amna, Das, Arighno, Finn, Daniel J., Levitsky, Josh, Holl, Jane L., Lloyd-Jones, Donald M., VanWagner, Lisa B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454906/
https://www.ncbi.nlm.nih.gov/pubmed/34557583
http://dx.doi.org/10.1097/TXD.0000000000001220
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author Campbell, Patrick T.
Kosirog, Megan
Aghaulor, Blessing
Gregory, Dyanna
Pine, Stewart
Daud, Amna
Das, Arighno
Finn, Daniel J.
Levitsky, Josh
Holl, Jane L.
Lloyd-Jones, Donald M.
VanWagner, Lisa B.
author_facet Campbell, Patrick T.
Kosirog, Megan
Aghaulor, Blessing
Gregory, Dyanna
Pine, Stewart
Daud, Amna
Das, Arighno
Finn, Daniel J.
Levitsky, Josh
Holl, Jane L.
Lloyd-Jones, Donald M.
VanWagner, Lisa B.
author_sort Campbell, Patrick T.
collection PubMed
description BACKGROUND. Chronic kidney disease (CKD) is associated with cardiovascular (CV) events, a leading complication in liver transplant recipients (LTRs). Timely subspecialty care is associated with improved clinical outcomes in patients with CKD. This study sought to assess associations between nephrology comanagement and CV events among LTRs at risk for or with CKD. METHODS. LTRs with CKD plus those at risk were identified in an inception cohort at a single tertiary care network between 2010 and 2016, using electronic health record data and manual chart review. CKD was defined as estimated glomerular filtration rate <60 mL/min/1.73 m(2) or International Classification of Diseases 9th or 10th revision code for CKD and at-risk CKD as estimated glomerular filtration rate 60–89 mL/min/1.73 m(2). Cox proportional hazard models assessed the association between nephrology comanagement and CV events among LTRs with or at risk for CKD. RESULTS. Among 602 LTRs followed for up to 6 y posttransplant, prevalence of CKD plus those at risk increased yearly (71% in year 1, 86% in year 6) (P < 0.0001). Rates of nephrology comanagement decreased yearly posttransplant (35% in year 1, 28% in year 6). In multivariable models, nephrology comanagement was associated with lower CV events (adjusted hazard ratio, 0.57; 95% confidence interval, 0.33–0.99). CONCLUSIONS. Among LTRs with CKD, nephrology comanagement may be associated with lower CV events. A prospective study is needed to identify the reasons for improved outcomes and barriers to nephrology referral.
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spelling pubmed-84549062021-09-22 Comanagement With Nephrologist Care Is Associated With Fewer Cardiovascular Events Among Liver Transplant Recipients With Chronic Kidney Disease Campbell, Patrick T. Kosirog, Megan Aghaulor, Blessing Gregory, Dyanna Pine, Stewart Daud, Amna Das, Arighno Finn, Daniel J. Levitsky, Josh Holl, Jane L. Lloyd-Jones, Donald M. VanWagner, Lisa B. Transplant Direct Liver Transplantation BACKGROUND. Chronic kidney disease (CKD) is associated with cardiovascular (CV) events, a leading complication in liver transplant recipients (LTRs). Timely subspecialty care is associated with improved clinical outcomes in patients with CKD. This study sought to assess associations between nephrology comanagement and CV events among LTRs at risk for or with CKD. METHODS. LTRs with CKD plus those at risk were identified in an inception cohort at a single tertiary care network between 2010 and 2016, using electronic health record data and manual chart review. CKD was defined as estimated glomerular filtration rate <60 mL/min/1.73 m(2) or International Classification of Diseases 9th or 10th revision code for CKD and at-risk CKD as estimated glomerular filtration rate 60–89 mL/min/1.73 m(2). Cox proportional hazard models assessed the association between nephrology comanagement and CV events among LTRs with or at risk for CKD. RESULTS. Among 602 LTRs followed for up to 6 y posttransplant, prevalence of CKD plus those at risk increased yearly (71% in year 1, 86% in year 6) (P < 0.0001). Rates of nephrology comanagement decreased yearly posttransplant (35% in year 1, 28% in year 6). In multivariable models, nephrology comanagement was associated with lower CV events (adjusted hazard ratio, 0.57; 95% confidence interval, 0.33–0.99). CONCLUSIONS. Among LTRs with CKD, nephrology comanagement may be associated with lower CV events. A prospective study is needed to identify the reasons for improved outcomes and barriers to nephrology referral. Lippincott Williams & Wilkins 2021-09-20 /pmc/articles/PMC8454906/ /pubmed/34557583 http://dx.doi.org/10.1097/TXD.0000000000001220 Text en Copyright © 2021 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Liver Transplantation
Campbell, Patrick T.
Kosirog, Megan
Aghaulor, Blessing
Gregory, Dyanna
Pine, Stewart
Daud, Amna
Das, Arighno
Finn, Daniel J.
Levitsky, Josh
Holl, Jane L.
Lloyd-Jones, Donald M.
VanWagner, Lisa B.
Comanagement With Nephrologist Care Is Associated With Fewer Cardiovascular Events Among Liver Transplant Recipients With Chronic Kidney Disease
title Comanagement With Nephrologist Care Is Associated With Fewer Cardiovascular Events Among Liver Transplant Recipients With Chronic Kidney Disease
title_full Comanagement With Nephrologist Care Is Associated With Fewer Cardiovascular Events Among Liver Transplant Recipients With Chronic Kidney Disease
title_fullStr Comanagement With Nephrologist Care Is Associated With Fewer Cardiovascular Events Among Liver Transplant Recipients With Chronic Kidney Disease
title_full_unstemmed Comanagement With Nephrologist Care Is Associated With Fewer Cardiovascular Events Among Liver Transplant Recipients With Chronic Kidney Disease
title_short Comanagement With Nephrologist Care Is Associated With Fewer Cardiovascular Events Among Liver Transplant Recipients With Chronic Kidney Disease
title_sort comanagement with nephrologist care is associated with fewer cardiovascular events among liver transplant recipients with chronic kidney disease
topic Liver Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454906/
https://www.ncbi.nlm.nih.gov/pubmed/34557583
http://dx.doi.org/10.1097/TXD.0000000000001220
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