Roadmap for the use of base editors to decipher drug mechanism of action

CRISPR base editors are powerful tools for large-scale mutagenesis studies. This kind of approach can elucidate the mechanism of action of compounds, a key process in drug discovery. Here, we explore the utility of base editors in an early drug discovery context focusing on G-protein coupled recepto...

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Detalles Bibliográficos
Autores principales: Aparicio-Prat, Estel, Yan, Dong, Mariotti, Marco, Bassik, Michael, Hess, Gaelen, Fortin, Jean-Philippe, Weston, Andrea, Xi, Hualin S., Stanton, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454938/
https://www.ncbi.nlm.nih.gov/pubmed/34547052
http://dx.doi.org/10.1371/journal.pone.0257537

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