Cargando…

Mild and Severe SARS-CoV-2 Infection Induces Respiratory and Intestinal Microbiome Changes in the K18-hACE2 Transgenic Mouse Model

Transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in millions of deaths and declining economies around the world. K18-hACE2 mice develop disease resembling severe SARS-CoV-2 infection in a virus dose-dependent manner. The relationship between SARS-CoV-2 an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seibert, Brittany, Cáceres, C. Joaquín, Cardenas-Garcia, Stivalis, Carnaccini, Silvia, Geiger, Ginger, Rajao, Daniela S., Ottesen, Elizabeth, Perez, Daniel R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455067/ https://www.ncbi.nlm.nih.gov/pubmed/34378965 http://dx.doi.org/10.1128/spectrum.00536-21

Ejemplares similares

Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model
por: Cáceres, C. Joaquín, et al.
Publicado: (2021)

Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2
por: Seibert, Brittany, et al.
Publicado: (2022)

Development of a swine RNA polymerase I driven Influenza reverse genetics system for the rescue of type A and B Influenza viruses
por: Seibert, Brittany, et al.
Publicado: (2020)

Alternative Strategy for a Quadrivalent Live Attenuated Influenza Virus Vaccine
por: Wan, Zhimin, et al.
Publicado: (2018)

Influenza antivirals and animal models
por: Caceres, C. Joaquin, et al.
Publicado: (2022)

Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses
por: Cáceres, C. Joaquín, et al.
Publicado: (2021)

Development of a Novel Live Attenuated Influenza A Virus Vaccine Encoding the IgA-Inducing Protein
por: Cáceres, C. Joaquín, et al.
Publicado: (2021)

Maternally-Derived Antibodies Protect against Challenge with Highly Pathogenic Avian Influenza Virus of the H7N3 Subtype
por: Cardenas-Garcia, Stivalis, et al.
Publicado: (2019)

Mutation E48K in PB1 Polymerase Subunit Improves Stability of a Candidate Live Attenuated Influenza B Virus Vaccine
por: Mo, Jongsuk, et al.
Publicado: (2021)

Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression
por: Carossino, Mariano, et al.
Publicado: (2022)

K18- and CAG-hACE2 Transgenic Mouse Models and SARS-CoV-2: Implications for Neurodegeneration Research
por: Dedoni, Simona, et al.
Publicado: (2022)

FluB-RAM and FluB-RANS: Genome Rearrangement as Safe and Efficacious Live Attenuated Influenza B Virus Vaccines
por: Cardenas-Garcia, Stivalis, et al.
Publicado: (2021)

Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice
por: Bar-On, Liat, et al.
Publicado: (2022)

In Vivo protection from SARS-CoV-2 infection by ATN-161 in k18-hACE2 transgenic mice
por: Amruta, Narayanappa, et al.
Publicado: (2021)

Effect of severe acute respiratory syndrome coronavirus 2 infection during pregnancy in K18-hACE2 transgenic mice
por: Kim, Byeongseok, et al.
Publicado: (2023)

Therapeutic Effect of C-Vx Substance in K18-hACE2 Transgenic Mice Infected with SARS-CoV-2
por: Ulbegi Polat, Hivda, et al.
Publicado: (2023)

Comparative pathology of the nasal epithelium in K18-hACE2 Tg mice, hACE2 Tg mice, and hamsters infected with SARS-CoV-2
por: Yu, Pin, et al.
Publicado: (2022)

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection
por: Rathnasinghe, Raveen, et al.
Publicado: (2020)

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection
por: Rathnasinghe, Raveen, et al.
Publicado: (2020)

Effects of simeprevir on the replication of SARS-CoV-2 in vitro and in transgenic hACE2 mice
por: Muturi, Elishiba, et al.
Publicado: (2022)

Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice
por: DeDiego, Marta L., et al.
Publicado: (2008)

The Tissue Distribution of SARS-CoV-2 in Transgenic Mice With Inducible Ubiquitous Expression of hACE2
por: Dolskiy, Alexander A., et al.
Publicado: (2022)

Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic mice
por: Vidal, Enric, et al.
Publicado: (2021)

Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice
por: Tarrés-Freixas, Ferran, et al.
Publicado: (2022)

Virulence Profiles of Wild-Type, P.1 and Delta SARS-CoV-2 Variants in K18-hACE2 Transgenic Mice
por: da Silva Santos, Yasmin, et al.
Publicado: (2023)

Intra- and inter-host evolution of H9N2 influenza A virus in Japanese quail
por: Ferreri, Lucas M, et al.
Publicado: (2022)

Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse
por: Seehusen, Frauke, et al.
Publicado: (2022)

COVID-19 Treatments and Pathogenesis Including Anosmia in K18-hACE2 mice
por: Zheng, Jian, et al.
Publicado: (2020)

Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice
por: Olivarria, Gema M., et al.
Publicado: (2021)

Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
por: Rosenfeld, Ronit, et al.
Publicado: (2021)

Highly susceptible SARS-CoV-2 model in CAG promoter–driven hACE2-transgenic mice
por: Asaka, Masamitsu N., et al.
Publicado: (2021)

An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo
por: Liu, Kuo, et al.
Publicado: (2023)

Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2023)

Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection
por: Moreau, Gregory Brett, et al.
Publicado: (2020)

Protocol for infecting and monitoring susceptible k18-hACE2 mice with SARS-CoV-2
por: Couto, Joana, et al.
Publicado: (2023)

Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice
por: Wong, Ting Y., et al.
Publicado: (2022)

K18-hACE2 mice develop respiratory disease resembling severe COVID-19
por: Yinda, Claude Kwe, et al.
Publicado: (2020)

K18-hACE2 mice develop respiratory disease resembling severe COVID-19
por: Yinda, Claude Kwe, et al.
Publicado: (2021)

SARS-CoV-2 infection of hACE2 transgenic mice causes severe lung inflammation and impaired function
por: Winkler, Emma S., et al.
Publicado: (2020)

Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice
por: Kumari, Pratima, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3tta84unb8h53tphtu804e8kta