Nanoparticle-based drug delivery systems for cancer therapy

Nanoparticle-based drug delivery system (DDS) is considered promising for cancer treatment. Compared with traditional DDS, the nanoparticle-based DDS shows improved efficacy by: 1) increasing half-life of vulnerable drugs and proteins, 2) improving the solubility of hydrophobic drugs, and 3) allowin...

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Detalles Bibliográficos
Autores principales: Dang, Yu, Guan, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455119/
https://www.ncbi.nlm.nih.gov/pubmed/34553138
http://dx.doi.org/10.1016/j.smaim.2020.04.001
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author Dang, Yu
Guan, Jianjun
author_facet Dang, Yu
Guan, Jianjun
author_sort Dang, Yu
collection PubMed
description Nanoparticle-based drug delivery system (DDS) is considered promising for cancer treatment. Compared with traditional DDS, the nanoparticle-based DDS shows improved efficacy by: 1) increasing half-life of vulnerable drugs and proteins, 2) improving the solubility of hydrophobic drugs, and 3) allowing controlled and targeted release of drugs in diseased site. This review mainly focuses on nanoparticle-based DDS fabricated from chitosan, silica, and poly (lactic-co-glycolic acid). Their fabrication methods and applications in cancer treatment are introduced. The current limitations and future perspectives of the nanoparticle-based DDS are discussed.
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spelling pubmed-84551192021-09-21 Nanoparticle-based drug delivery systems for cancer therapy Dang, Yu Guan, Jianjun Smart Mater Med Article Nanoparticle-based drug delivery system (DDS) is considered promising for cancer treatment. Compared with traditional DDS, the nanoparticle-based DDS shows improved efficacy by: 1) increasing half-life of vulnerable drugs and proteins, 2) improving the solubility of hydrophobic drugs, and 3) allowing controlled and targeted release of drugs in diseased site. This review mainly focuses on nanoparticle-based DDS fabricated from chitosan, silica, and poly (lactic-co-glycolic acid). Their fabrication methods and applications in cancer treatment are introduced. The current limitations and future perspectives of the nanoparticle-based DDS are discussed. 2020-04-13 2020 /pmc/articles/PMC8455119/ /pubmed/34553138 http://dx.doi.org/10.1016/j.smaim.2020.04.001 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Dang, Yu
Guan, Jianjun
Nanoparticle-based drug delivery systems for cancer therapy
title Nanoparticle-based drug delivery systems for cancer therapy
title_full Nanoparticle-based drug delivery systems for cancer therapy
title_fullStr Nanoparticle-based drug delivery systems for cancer therapy
title_full_unstemmed Nanoparticle-based drug delivery systems for cancer therapy
title_short Nanoparticle-based drug delivery systems for cancer therapy
title_sort nanoparticle-based drug delivery systems for cancer therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455119/
https://www.ncbi.nlm.nih.gov/pubmed/34553138
http://dx.doi.org/10.1016/j.smaim.2020.04.001
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