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Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo

Inherited deficiency of the antiprotease alpha-1 antitrypsin (AAT) is associated with liver failure and early-onset emphysema. In mice, in vivo lentiviral transduction of alveolar macrophages (AMs) has been described to yield protective pulmonary AAT levels and ameliorate emphysema development. We h...

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Detalles Bibliográficos
Autores principales:	Janosz, Ewa, Hetzel, Miriam, Spielmann, Hanna, Tumpara, Srinu, Rossdam, Charlotte, Schwabbauer, Marc, Kloos, Doreen, von Kaisenberg, Constantin, Schambach, Axel, Buettner, Falk F. R., Janciauskiene, Sabina, Lachmann, Nico, Moritz, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455329/ https://www.ncbi.nlm.nih.gov/pubmed/34276045 http://dx.doi.org/10.1038/s41434-021-00269-3

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