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Cas9-directed immune tolerance in humans—a model to evaluate regulatory T cells in gene therapy?
The dichotomic nature of the adaptive immune response governs the outcome of clinical gene therapy. On the one hand, neutralizing antibodies and cytotoxic T cells can have a dramatic impact on the efficacy and safety of human gene therapies. On the other hand, regulatory T cells (Treg) can promote t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455332/ https://www.ncbi.nlm.nih.gov/pubmed/33574580 http://dx.doi.org/10.1038/s41434-021-00232-2 |