Automated production of CCR5-negative CD4(+)-T cells in a GMP-compatible, clinical scale for treatment of HIV-positive patients

Ex-vivo gene editing in T lymphocytes paves the way for novel concepts of immunotherapy. One of those strategies is directed at the protection of CD4(+)-T helper cells from HIV infection in HIV-positive individuals. To this end, we have developed and optimised a CCR5-targeting TALE nuclease, CCR5-Uc...

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Detalles Bibliográficos
Autores principales: Schwarze, Lea Isabell, Sonntag, Tanja, Wild, Stefan, Schmitz, Sabrina, Uhde, Almut, Fehse, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455337/
https://www.ncbi.nlm.nih.gov/pubmed/33867524
http://dx.doi.org/10.1038/s41434-021-00259-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455337/
https://www.ncbi.nlm.nih.gov/pubmed/33867524
http://dx.doi.org/10.1038/s41434-021-00259-5

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