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The genetic architecture of structural left–right asymmetry of the human brain

Left–right hemispheric asymmetry is an important aspect of healthy brain organization for many functions including language, and it can be altered in cognitive and psychiatric disorders. No mechanism has yet been identified for establishing the human brain’s left–right axis. We performed multivariat...

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Autores principales: Sha, Zhiqiang, Schijven, Dick, Carrion-Castillo, Amaia, Joliot, Marc, Mazoyer, Bernard, Fisher, Simon E., Crivello, Fabrice, Francks, Clyde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455338/
https://www.ncbi.nlm.nih.gov/pubmed/33723403
http://dx.doi.org/10.1038/s41562-021-01069-w
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author Sha, Zhiqiang
Schijven, Dick
Carrion-Castillo, Amaia
Joliot, Marc
Mazoyer, Bernard
Fisher, Simon E.
Crivello, Fabrice
Francks, Clyde
author_facet Sha, Zhiqiang
Schijven, Dick
Carrion-Castillo, Amaia
Joliot, Marc
Mazoyer, Bernard
Fisher, Simon E.
Crivello, Fabrice
Francks, Clyde
author_sort Sha, Zhiqiang
collection PubMed
description Left–right hemispheric asymmetry is an important aspect of healthy brain organization for many functions including language, and it can be altered in cognitive and psychiatric disorders. No mechanism has yet been identified for establishing the human brain’s left–right axis. We performed multivariate genome-wide association scanning of cortical regional surface area and thickness asymmetries, and subcortical volume asymmetries, using data from 32,256 participants from the UK Biobank. There were 21 significant loci associated with different aspects of brain asymmetry, with functional enrichment involving microtubule-related genes and embryonic brain expression. These findings are consistent with a known role of the cytoskeleton in left–right axis determination in other organs of invertebrates and frogs. Genetic variants associated with brain asymmetry overlapped with those associated with autism, educational attainment and schizophrenia. Comparably large datasets will likely be required in future studies, to replicate and further clarify the associations of microtubule-related genes with variation in brain asymmetry, behavioural and psychiatric traits.
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spelling pubmed-84553382021-10-07 The genetic architecture of structural left–right asymmetry of the human brain Sha, Zhiqiang Schijven, Dick Carrion-Castillo, Amaia Joliot, Marc Mazoyer, Bernard Fisher, Simon E. Crivello, Fabrice Francks, Clyde Nat Hum Behav Article Left–right hemispheric asymmetry is an important aspect of healthy brain organization for many functions including language, and it can be altered in cognitive and psychiatric disorders. No mechanism has yet been identified for establishing the human brain’s left–right axis. We performed multivariate genome-wide association scanning of cortical regional surface area and thickness asymmetries, and subcortical volume asymmetries, using data from 32,256 participants from the UK Biobank. There were 21 significant loci associated with different aspects of brain asymmetry, with functional enrichment involving microtubule-related genes and embryonic brain expression. These findings are consistent with a known role of the cytoskeleton in left–right axis determination in other organs of invertebrates and frogs. Genetic variants associated with brain asymmetry overlapped with those associated with autism, educational attainment and schizophrenia. Comparably large datasets will likely be required in future studies, to replicate and further clarify the associations of microtubule-related genes with variation in brain asymmetry, behavioural and psychiatric traits. Nature Publishing Group UK 2021-03-15 2021 /pmc/articles/PMC8455338/ /pubmed/33723403 http://dx.doi.org/10.1038/s41562-021-01069-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sha, Zhiqiang
Schijven, Dick
Carrion-Castillo, Amaia
Joliot, Marc
Mazoyer, Bernard
Fisher, Simon E.
Crivello, Fabrice
Francks, Clyde
The genetic architecture of structural left–right asymmetry of the human brain
title The genetic architecture of structural left–right asymmetry of the human brain
title_full The genetic architecture of structural left–right asymmetry of the human brain
title_fullStr The genetic architecture of structural left–right asymmetry of the human brain
title_full_unstemmed The genetic architecture of structural left–right asymmetry of the human brain
title_short The genetic architecture of structural left–right asymmetry of the human brain
title_sort genetic architecture of structural left–right asymmetry of the human brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455338/
https://www.ncbi.nlm.nih.gov/pubmed/33723403
http://dx.doi.org/10.1038/s41562-021-01069-w
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