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Ileal Derived Organoids From Crohn’s Disease Patients Show Unique Transcriptomic and Secretomic Signatures

BACKGROUND & AIMS: We used patient-derived organoids (PDOs) to study the epithelial-specific transcriptional and secretome signatures of the ileum during Crohn’s disease (CD) with varying phenotypes to screen for disease profiles and potential druggable targets. METHODS: RNA sequencing was perfo...

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Detalles Bibliográficos
Autores principales:	Niklinska-Schirtz, Barbara Joanna, Venkateswaran, Suresh, Anbazhagan, Murugadas, Kolachala, Vasantha L., Prince, Jarod, Dodd, Anne, Chinnadurai, Raghavan, Gibson, Gregory, Denson, Lee A., Cutler, David J., Jegga, Anil G., Matthews, Jason D., Kugathasan, Subra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455365/ https://www.ncbi.nlm.nih.gov/pubmed/34271224 http://dx.doi.org/10.1016/j.jcmgh.2021.06.018

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