Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

Precise cis-regulatory control of gene expression is essential for normal embryogenesis and tissue development. The BMP antagonist Gremlin1 (Grem1) is a key node in the signalling system that coordinately controls limb bud development. Here, we use mouse reverse genetics to identify the enhancers in...

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Detalles Bibliográficos
Autores principales: Malkmus, Jonas, Ramos Martins, Laurène, Jhanwar, Shalu, Kircher, Bonnie, Palacio, Victorio, Sheth, Rushikesh, Leal, Francisca, Duchesne, Amandine, Lopez-Rios, Javier, Peterson, Kevin A., Reinhardt, Robert, Onimaru, Koh, Cohn, Martin J., Zuniga, Aimée, Zeller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455560/
https://www.ncbi.nlm.nih.gov/pubmed/34548488
http://dx.doi.org/10.1038/s41467-021-25810-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455560/
https://www.ncbi.nlm.nih.gov/pubmed/34548488
http://dx.doi.org/10.1038/s41467-021-25810-1

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