Cargando…

Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

Precise cis-regulatory control of gene expression is essential for normal embryogenesis and tissue development. The BMP antagonist Gremlin1 (Grem1) is a key node in the signalling system that coordinately controls limb bud development. Here, we use mouse reverse genetics to identify the enhancers in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malkmus, Jonas, Ramos Martins, Laurène, Jhanwar, Shalu, Kircher, Bonnie, Palacio, Victorio, Sheth, Rushikesh, Leal, Francisca, Duchesne, Amandine, Lopez-Rios, Javier, Peterson, Kevin A., Reinhardt, Robert, Onimaru, Koh, Cohn, Martin J., Zuniga, Aimée, Zeller, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455560/ https://www.ncbi.nlm.nih.gov/pubmed/34548488 http://dx.doi.org/10.1038/s41467-021-25810-1

Ejemplares similares

Conserved and species-specific chromatin remodeling and regulatory dynamics during mouse and chicken limb bud development
por: Jhanwar, Shalu, et al.
Publicado: (2021)

Optimized protocol for whole-mount RNA fluorescent in situ hybridization using oxidation-mediated autofluorescence reduction on mouse embryos
por: Morabito, Angela, et al.
Publicado: (2023)

Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds
por: Zuniga, Aimée, et al.
Publicado: (2012)

Gremlins : ¡ya estamos aquí!
por: Spielberg, Steven, 1946-

GREMLIN2 and atrial fibrillation
Publicado: (2013)

Gremlin in the Vitreous of Patients with Proliferative Diabetic Retinopathy and the Downregulation of Gremlin in Retinal Pigment Epithelial Cells
por: Qin, Dong, et al.
Publicado: (2020)

Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles
por: Niiyama, Shiro, et al.
Publicado: (2022)

Gremlin Enhances the Determined Path to Cardiomyogenesis
por: Kami, Daisuke, et al.
Publicado: (2008)

SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning
por: Gamart, Julie, et al.
Publicado: (2021)

Gremlin-1 Concentrations Are Correlated with the Severity of Knee Osteoarthritis
por: Yi, Jun, et al.
Publicado: (2016)

Production and Biochemical Characterization of Dimeric Recombinant Gremlin-1
por: Mitola, Stefania, et al.
Publicado: (2022)

Circulating Gremlin-1 is elevated in systemic sclerosis patients
por: O’Reilly, Steven
Publicado: (2021)

Analysis of Gremlin 1 Levels Following Sleeve Gastrectomy
por: Alregaiey, Khalid A, et al.
Publicado: (2023)

5-Methylcytosine and 5-Hydroxymethylcytosine Signatures Underlying Pediatric Cancers
por: Jhanwar, Shalu, et al.
Publicado: (2019)

Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13
por: Sheth, Rushikesh, et al.
Publicado: (2016)

Gremlin-2 is a BMP antagonist that is regulated by the circadian clock
por: Yeung, Ching-Yan Chloé, et al.
Publicado: (2014)

Tubular Overexpression of Gremlin Induces Renal Damage Susceptibility in Mice
por: Droguett, Alejandra, et al.
Publicado: (2014)

Structure of Gremlin-1 and analysis of its interaction with BMP-2
por: Kišonaitė, Miglė, et al.
Publicado: (2016)

Expression of gremlin1 in gastric cancer and its clinical significance
por: Yamasaki, Yoichi, et al.
Publicado: (2018)

Generation and Applications of a DNA Aptamer against Gremlin-1
por: Li, Qian, et al.
Publicado: (2017)

Pancreatic stromal Gremlin 1 expression during pancreatic tumorigenesis
por: Davis, Joy M., et al.
Publicado: (2020)

Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action
por: Moustakas, Aristidis, et al.
Publicado: (2022)

Correction: Tubular Overexpression of Gremlin Induces Renal Damage Susceptibility in Mice
Publicado: (2014)

Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma
por: Yin, Miao, et al.
Publicado: (2017)

REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature
por: Shaik, Shavali, et al.
Publicado: (2017)

Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis
por: Droguett, Alejandra, et al.
Publicado: (2019)

SAT-LB037 Gremlin-2 Regulates Ovarian Function in Mice
por: Pangas, Stephanie, et al.
Publicado: (2019)

Prognostic and clinicopathological significance of Hapto and Gremlin1 expression in extrahepatic cholangiocarcinoma
por: Wu, Zhengchun, et al.
Publicado: (2020)

Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin
por: Kawagishi-Hotta, Mika, et al.
Publicado: (2021)

Putative cis-Regulatory Elements Associated with Heat Shock Genes Activated During Excystation of Cryptosporidium parvum
por: Cohn, Benjamin, et al.
Publicado: (2010)

Gremlin-1 Induces BMP-Independent Tumor Cell Proliferation, Migration, and Invasion
por: Kim, Minsoo, et al.
Publicado: (2012)

Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt
por: Dutton, Louise R., et al.
Publicado: (2019)

Overexpression of Gremlin 1 by sonic hedgehog signaling promotes pancreatic cancer progression
por: Yu, Yongtian, et al.
Publicado: (2018)

Gremlin1 plays a key role in kidney development and renal fibrosis
por: Church, Rachel H., et al.
Publicado: (2017)

Gremlin 1 depletion in vivo causes severe enteropathy and bone marrow failure
por: Rowan, Simon C, et al.
Publicado: (2020)

Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression
por: Ren, Jiang, et al.
Publicado: (2019)

Association of Gremlin-2 gene polymorphisms with osteoporosis risk in Chinese postmenopausal women
por: Feng, Yu, et al.
Publicado: (2020)

Gremlin 2 could explain the reduced capacity of browning of visceral adipose tissue
por: Moreno-Navarrete, José María
Publicado: (2022)

Molecular signatures identify immature mesenchymal progenitors in early mouse limb buds that respond differentially to morphogen signaling
por: Reinhardt, Robert, et al.
Publicado: (2019)

Gremlin is Overexpressed in Lung Adenocarcinoma and Increases Cell Growth and Proliferation in Normal Lung Cells
por: Mulvihill, Michael S., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_jo270tnc9koouhm2n269l09alv