Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex

In amyotrophic lateral sclerosis (ALS), TAR DNA-binding protein 43 (TDP-43), which is encoded by TARDBP, forms aggregates in the motor cortex. This aggregate formation may be triggered by an increase in the TDP-43 level with aging. However, the amount of TDP-43 is autoregulated by alternative splici...

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Detalles Bibliográficos
Autores principales: Koike, Yuka, Sugai, Akihiro, Hara, Norikazu, Ito, Junko, Yokoseki, Akio, Ishihara, Tomohiko, Yamagishi, Takuma, Tsuboguchi, Shintaro, Tada, Mari, Ikeuchi, Takeshi, Kakita, Akiyoshi, Onodera, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455575/
https://www.ncbi.nlm.nih.gov/pubmed/34548609
http://dx.doi.org/10.1038/s42003-021-02621-0

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