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Exploration of the structural requirements of Aurora Kinase B inhibitors by a combined QSAR, modelling and molecular simulation approach

Aurora kinase B plays an important role in the cell cycle to orchestrate the mitotic process. The amplification and overexpression of this kinase have been implicated in several human malignancies. Therefore, Aurora kinase B is a potential drug target for anticancer therapies. Here, we combine atom-...

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Detalles Bibliográficos
Autores principales:	Ashraf, Sajda, Ranaghan, Kara E., Woods, Christopher J., Mulholland, Adrian J., Ul-Haq, Zaheer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455585/ https://www.ncbi.nlm.nih.gov/pubmed/34548506 http://dx.doi.org/10.1038/s41598-021-97368-3

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